Cargando…
Cancer gene therapy by viral and non-viral vectors /
"Translational medicine has opened the gateway to the era of personalized medicine. No longer a one-size-fits-all approach, the treatment of cancer is now based on an understanding of underlying biologic mechanisms and is increasingly being tailored to the molecular specificity of a tumor. Gene...
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, New Jersey :
Wiley Blackwell,
[2014]
|
| Colección: | Translational oncology (Series) ;
4. |
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cancer Gene Therapy by Viral and Non-viral Vectors; Copyright; Contents; List of Contributors; Series Foreword; Preface; Part I Delivery Systems; 1 Translational Cancer Research: Gene Therapy by Viral and Non-viral Vectors, ; Adenovirus; Oncolytic Adenoviruses for Treatment of Cancer; Vaccinia Virus; Herpes Virus; Parvovirus; Final Remarks; References; 2 Retroviruses for Cancer Therapy; Introduction; Overview of Retroviral Vectors; Gammaretroviral and Alpharetroviral Vectors; Foamyviral (Spumaviral) Vectors; HIV-1-Derived Lentiviral Vectors; Evolution of HIV-1-Derived Lentiviral Vectors
- Retroviral Vector-Mediated RNAi Therapy: From Basic Science to Clinical TrialConcluding Remarks and Challenges; Acknowledgments; References; 3 DNA Plasmids for Non-viral Gene Therapy of Cancer; Delivery; Expression of Transgenes from DNA Plasmid; Safety; Therapeutic Applications; Summary; References; 4 Cancer Therapy with RNAi Delivered by Non-viral Membrane/Core Nanoparticles; Introduction; Barriers; Overcoming Delivery Barriers; Putting it All Together: Model Examples of Innovative and Successful NPs; Conclusions; Acknowledgments; References; Part II Targeted Expression
- 5 Cancer Gene Therapy by Tissue-specific and Cancer-targeting PromotersIntroduction; Cancer-Specific Promoters; Cancer-Targeting Promoters; Engineered Systems that Enhance Promoter Activity; Conclusion; References; 6 MicroRNAs as Drugs and Drug Targets in Cancer; Introduction; MiRNA and its Functioning Mechanism; MiRNA and Cancers; MiRNA in Other Diseases; MiRNA Therapeutics; Challenges; Outlook; References; Part III Principles of Clinical Trials in Gene Therapy; 7 Regulatory Issues for Manufacturers of Viral Vectors and Vector-transduced Cells for Phase I/ II Trials; Introduction
- Development of Good Manufacturing PracticescGMP Requirements; cGMP Compliance; Practical Compliance: One Center's Experience; Conclusions; Acknowledgments; References; 8 US Regulations Governing Clinical Trials in Gene Therapy; Introduction; NIH OBA and RAC; IBC; IRB; FDA; Protocol; Consent Form; Multisite Protocols; Conclusion; References; 9 Remaining Obstacles to the Success of Cancer Gene Therapy; Introduction; Drug-Development Pathways; Broadening the Appeal of Complex Biologics; Clinical Trial Design and Execution; Conceptual Limitations; Conclusions; References; Index