Antibiotics : Targets, Mechanisms and Resistance.

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery. To meet the medical need for next-generation antibiotics, a more rational approach to antibiotic development is clearly needed. Opening with...

Full description

Bibliographic Details
Call Number:Libro Electrónico
Main Author: Gualerzi, Claudio O.
Other Authors: Brandi, Letizia, Fabbretti, Attilio, Pon, Cynthia L.
Format: Electronic eBook
Language:Inglés
Published: Hoboken : Wiley, 2013.
Subjects:
Antibiotics.
MEDICAL > Pharmacology.
Antibiotics
Online Access:Texto completo
Table of Contents:
  • A chemist's survey of different antibiotic classes
  • Antibacterial discovery: problems and possibilities
  • Impact of microbial natural products on antibacterial drug discovery
  • Antibiotics and resistance: a fatal attraction
  • Fitness costs of antibiotic resistance
  • Inhibitors of cell-wall synthesis
  • Inhibitors of bacetrial cell partitioning
  • The membrane as a novel target site for antibiotics to kill persisting bacterial pathogens
  • Bacterial membrane, a key for controlling drug influx and efflux
  • Interference with bacterial cell-to-cell chemical signaling in development of new anti-infectives
  • Recent developments in inhibitors of bacterial type IIA topoisomerases
  • Antibiotics targeting bacterial RNA polymerase
  • Inhibitors targeting riboswitches and ribozymes
  • Targeting ribonuclease P
  • Involvement of ribosome biogenesis in antibiotic functions, acquired resistance, and future opportunities in drug discovery
  • Aminoacyl-tRNA synthetase inhibitors
  • Antibiotics targeting translation initiation in prokaryotes
  • Inhibitors of bacterial elongation factor EF-Tu
  • Aminoglycoside antibiotics: structural decoding of inhibitors targeting the ribosomal decoding A site
  • Reptidyltransferase inhibitors of the bacterial ribosome
  • Antibiotics inhibiting the translocation step of protein elongation on the ribosome
  • Antibiotics at the ribosomal exit tunnel
  • selected structual aspects
  • Targeting HSP70 to fight cancer and bad bugs: one and the same battle?

Similar Items