DNA repair, genetic instability, and cancer /

This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Wei, Qingyi, Li, Lei, Dr, Chen, David, Dr
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Singapore ; Hackensack, N.J. : World Scientific Pub. Co., ©2007.
Temas:
Tumors > Etiology.
Tumors > Genetics.
DNA damage > Genetics.
DNA repair > Genetics.
Cancer > Genetic aspects.
Neoplasms > etiology
Neoplasms > genetics
DNA Damage > genetics
DNA Repair > genetics
DNA Repair-Deficiency Disorders
Genetic Predisposition to Disease
Tumeurs > Étiologie.
Tumeurs > Génétique.
ADN > Lésions > Génétique.
ADN > Réparation > Génétique.
Cancer > Aspect génétique.
HEALTH & FITNESS > Diseases > Cancer.
MEDICAL > Oncology.
Cancer > Genetic aspects
Tumors > Etiology
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Ch. 1. DNA damage sensing and signaling / Jamie L. Wood and Junjie Chen
  • ch. 2. Base excision repair / Bo Hang
  • ch. 3. Nucleotide excision repair / Lei Li
  • ch. 4. DNA mismatch repair: biological functions and molecular mechanisms / Guo-Min Li
  • ch. 5. Mammalian homologous recombination repair and cancer intervention / Zhiyuan Shen and Jac A. Nickoloff
  • ch. 6. Role of non-homologous end joining in the repair of DNA double-strand breaks / Sandeep Burma, Benjamin Chen and David J. Chen
  • ch. 7. A DNA-damage response network of fanconi anemia and BRCA proteins / Rong Guo and Weidong Wang
  • ch. 8. Structure and function of DNA repair proteins: lesion recognition / Wei Yang
  • ch. 9. DNA damage tolerance and translesion synthesis / Fang Xu, Yingnian Yu and Wei Xiao
  • ch. 10. Nucleases in DNA repair, replication and recombination: flap endonuclease-1 as a paradigm / Purnima Singh and Binghui Shen
  • ch. 11. Integrative genomics and epigenomics: application in cancer research / Maxwell P. Lee
  • ch. 12. Molecular epidemiology of DNA repair and cancer susceptibility: a review of population-based studies / Zhibin Hu, Li-E Wang and Qingyi Wei.

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