Cargando…
Protein Oxidation and Aging.
As the lifespan of humans increases, research into aging and its related pathological conditions is gaining momentum. This book is the first to explain protein oxidation and the aging process, focusing on the connection between protein disturbances and the oxidative stress that cells continually und...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | , , |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Chicester :
Wiley,
2012.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Title page; Copyright page; Contents; Introduction to the Wiley Series on Protein and Peptide Science; Preface; 1: Oxidative Stress and Protein Oxidation; 1.1 The Large Variety of Protein Oxidation Products; 1.1.1 Primary Protein Oxidation Products; 1.1.2 Reactive Compounds Mediating in Protein Oxidation; 1.1.3 Enzymatic Systems Playing a Role in Protein Oxidation; 1.1.4 Protein Oxidation in Cells and Cellular Structures; 1.2 Reversible Oxidative Modifications; 1.2.1 Methionine Sulfoxides and Methionine Modifications; 1.2.2 Cysteine Modifications and Disulfide Bond Formation.
- 1.2.3 Surface Hydrophobicity Modifications1.3 Irreversible Oxidation Products; 1.3.1 Protein Oxidation and Enzymatic Posttranslational Modifications; 1.3.2 Deamidation and Transamination; 1.3.3 Protein Glycation and AGEs; 1.3.4 Racemization; 1.3.5 Nitrosylation; 1.3.6 Tyrosyl Radicals and Nitrotyrosines; 1.3.7 Protein Carbonyls; 1.3.8 Aldehyde-Protein Reactions; 1.3.9 Cross-Linking of Proteins; 1.4 The Oxidation of Extracellular Matrix, Membrane and Cytoskeletal Proteins; 1.4.1 Collagen; 1.4.2 Elastin; 1.4.3 The Oxidation of Membrane Proteins; 1.4.4 Band 3; 1.4.5 Actin.
- 1.5 Mechanism and Factors Influencing the Formation of Protein Oxidation Products1.5.1 Redox Status; 1.5.2 Protein Turnover; 1.5.3 Metal-Catalyzed Oxidation (MCO); 1.5.4 Heat Shock Proteins; 1.6 Protein Aggregates: Formation and Specific Metabolic Effects; 1.6.1 Accumulation of Oxidized Proteins; 1.6.2 Lipofuscin and Ceroid; 1.7 Methods to Measure Protein Oxidation Products in Research Laboratories; 1.7.1 Determination of Methionine Sulfoxide Reduction and Methionine Oxidation; 1.7.2 Determination of Protein Glycation and Adducts; 1.7.3 Analysis of Isoaspartate Formation.
- 1.7.4 Measurement of Fragmentation1.7.5 Measurement of Tyrosine Oxidation; 1.7.6 Protein Carbonyl Measurement; 1.7.7 Radioactive Labeling Protocols for Proteolysis and Aggregation Measurements; 1.7.8 Standard Chromatographic Methods for the Measurement of Protein Modifications; 1.7.9 Liquid Chromatography Techniques Supported by Mass Spectrometry; 1.7.10 GC/MS; 1.7.11 Analysis of Protein-Bound 3-Nitrotyrosine by a Competitive ELISA Method; 1.7.12 Protein Oxidation Products as Biomarkers in Clinical Science; References; 2: Removal of Oxidized Proteins.
- 2.1 The Limited Repair of Some Oxidized Proteins2.1.1 Thiol Repair; 2.1.2 Methionine Sulfoxide Reductases; 2.2 Proteolysis; 2.2.1 The Proteasomal System and Its Role in the Degradation of Oxidized Proteins; 2.3 The Role of Other Proteases in the Fate of Oxidized Proteins; 2.3.1 Lysosomal Degradation of Oxidized Proteins and the Role of Autophagy; 2.3.2 Mitochondrial Degradation of Oxidized Proteins and the Lon Protease; 2.3.3 The Uptake of Extracellular Oxidized Proteins and the Role of the Proteasome in Their Degradation; 2.3.4 Calpains and the Degradation of Oxidized Proteins.