Tabla de Contenidos:
  • Review of the Hanford Thyroid Disease Study Draft Final Report
  • Copyright
  • ACKNOWLEDGEMENTS
  • Contents
  • Public Summary
  • BACKGROUND
  • DESIGN OF THE HTDS
  • Estimated Radiation Exposures
  • Analysis of HTDS Data
  • Statistical Power and the HTDS Interpretation
  • Communication of HTDS Results to the Public
  • Concluding Remarks
  • Executive Summary
  • BACKGROUND
  • EPIDEMIOLOGIC AND CLINICAL METHODS AND DATA COLLECTION
  • Conclusions:
  • Recommendations:
  • DOSIMETRY
  • Conclusions:
  • Recommendations:
  • STATISTICAL ANALYSES
  • Conclusions:Recommendations:
  • STATISTICAL POWER AND INTERPRETATION OF THE STUDY
  • Conclusions:
  • Recommendations:
  • COMMUNICATION OF THE STUDY RESULTS TO THE PUBLIC
  • Conclusions:
  • Recommendations:
  • SUMMARY OF RESPONSES TO THE CDC'S QUESTIONS
  • 1 Introduction
  • 2 Overview of the HTDS Draft Final Report and Organization of the Committee's Report
  • 3 Evaluation of Epidemiologic and Clinical Methods
  • EVALUATION OF EPIDEMIOLOGIC METHODS
  • MILK-CONSUMPTION ESTIMATION
  • EVALUATION OF CLINICAL-DATA COLLECTION
  • COMPLETENESS OF ASCERTAINMENT OF THYROID DISEASESUSCEPTIBILITY FACTORS FOR THYROID DISEASE
  • EVALUATION OF MORTALITY DATA
  • AMERICAN INDIAN TRIBAL ISSUES
  • 4 Evaluation of Dosimetric Methods and Results
  • BACKGROUND
  • HEDR CALCULATIONS OF ENVIRONMENTAL CONCENTRATIONS OF 131I FROM HANFORD AND RESULTING DOSES: ASSESSME ...
  • Source Term:
  • Concentration of131I in Pasture Grass at Time of Fallout:
  • Mean Time of Residence of 131I on Pasture Grass:
  • Pasture Intake by Cows:
  • Transfer Coefficient of 131I from Cow's Intake to Milk
  • Milk-Distribution Factor:Milk-Consumption Rate:
  • Thyroid Dose Coefficient:
  • HEDR DOSIMETRY-MODEL VALIDATION
  • Thyroid Burdens
  • Milk Concentrations
  • Concentrations in Vegetation
  • Concentrations in Air
  • Conclusions
  • Possible Underestimation or Overestimation of Doses
  • DOSE UNCERTAINTIES
  • 131I FROM THE NEVADA TEST SITE AND GLOBAL FALLOUT
  • OTHER SOURCES OF RADIATION EXPOSURE
  • 5 Evaluation of Statistical Data Analysis
  • MODE OF PRESENTATION OF RESULTS
  • TYPES OF ANALYSES AND RELATED DOSIMETRY-ERROR ISSUES
  • ANALYSIS OF POTENTIAL CONFOUNDING OR EFFECT-MODIFYING VARIABLESASSUMPTION OF EQUIVALENT RADIATION EFFECT FOR MALES AND FEMALES
  • ANALYSES BY AGE AT EXPOSURE
  • OUT-OF-AREA ANALYSES
  • GEOSTRATUM VERSUS DISEASE
  • GENERAL-POPULATION COMPARISON AND SCREENING ISSUES
  • ANALYSES OF SOURCE OF PERSONAL-EXPOSURE INFORMATION
  • 6 Statistical Power and Interpretation of the Study
  • FACTORS IN STATISTICAL POWER
  • SAMPLE SIZE AND ASSUMED BACKGROUND PREVALENCE OF DISEASE
  • EFFECT OF DOSIMETRY ERROR ON STATISTICAL POWER
  • VIOLATION OF THE BERKSON ERROR ASSUMPTION