Evolution of translational omics : lessons learned and the path forward /

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detec...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: Institute of Medicine (U.S.). Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials (sponsoring body.)
Otros Autores: Micheel, Christine (Editor ), Nass, Sharyl J. (Editor ), Omenn, Gilbert S. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Washington, D.C. : National Academies Press, [2012]
Colección:Online access: National Academy of Sciences National Academies Press.
Online access: NCBI NCBI Bookshelf.
Temas:
Genomics > Technology.
Genomics > Data processing.
Genetic translation > Technology.
Biomolecules > Analysis.
Biomolecules > Data processing.
Bioinformatics > Technology.
Data mining > Analysis.
Biotechnology.
Genomics.
Genomics
Validation Studies as Topic
Molecular Diagnostic Techniques
Biotechnology
Translational Research, Biomedical.
Génomique > Technologie.
Génomique > Informatique.
Traduction génétique > Technologie.
Biomolécules > Analyse.
Biomolécules > Informatique.
Bio-informatique > Technologie.
Exploration de données (Informatique) > Analyse.
Biotechnologie.
Génomique.
bioengineering.
SCIENCE > Life Sciences > Biochemistry.
Biomolecules > Analysis
Genomics > Data processing
Acceso en línea:Texto completo
Descripción
Sumario:Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Notas:Title from PDF title page.
Descripción Física:1 online resource (1 PDF file (xv, 338 pages) : illustrations
Bibliografía:Includes bibliographical references.
ISBN:9780309224192
0309224195

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