Apoptosis : Physiology and Pathology.

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Contributions from experts in the field focus on aspects of apoptosis, or cell death, from fundamental processes to apoptosis-related diseases.

Bibliographic Details
Call Number:Libro Electrónico
Main Author: Reed, John C.
Other Authors: Green, Douglas R.
Format: Electronic eBook
Language:Inglés
Published: Cambridge : Cambridge University Press, 2011.
Subjects:
Apoptosis.
Apoptosis
Apoptosis > physiology
Cell Death
Apoptose.
dissertations.
Academic theses
Academic theses.
Thèses et écrits académiques.
Online Access:Texto completo
Table of Contents:
  • Cover; Title; Copyright; Contents; Contributors; Part I General Principles of Cell Death; 1 Human Caspases
  • Apoptosis and Inflammation Signaling Proteases; 1. PROTEASE SIGNALING IN APOPTOSIS AND INFLAMMATION; 1.1. Apoptosis and limited proteolysis; 1.2. Caspase evolution; 2. ACTIVATION MECHANISMS; 2.1. Initiator caspases- activation by dimerization; 2.2. The activation platforms; 2.3. Executioner caspases- activation by cleavage; 2.4. Proteolytic maturation; 3. CASPASE SUBSTRATES; 4. REGULATION BY NATURAL INHIBITORS; REFERENCES; 2 Inhibitor of Apoptosis Proteins.
  • 1. THE BIR DOMAIN DEFINES MEMBERSHIP IN THE IAP FAMILY2. CELLULAR FUNCTIONS AND PHENOTYPES OF IAP; 3. IN VIVO FUNCTIONS OF IAP FAMILY PROTEINS; 4. SUBCELLULAR LOCATIONS OF IAP; 5. IAP AS CASPASE INHIBITORS; 6. IAP AS E3 LIGASES; 7. IAP AND SIGNAL TRANSDUCTION; 8. IAP-IAP INTERACTIONS; 9. POST-TRANSLATIONAL MODIFICATIONS OF BIR PROTEINS; 10. ENDOGENOUS ANTAGONISTS OF IAP; 11. IAPs AND DISEASE; SUGGESTED READINGS; 3 Death Domain-Containing Receptors
  • Decisions between Suicide and Fire; 1. INTRODUCTION; 2. RECEPTOR-LIGAND SYSTEMS WITH PRIMARILY PROAPOPTOTIC FUNCTIONS.
  • 2.1. The CD95 (Fas/APO-1)system2.1.1. CD95 and CD95L: discovery of the first direct apoptosis-inducing receptor-ligand system; 2.1.2. Biochemistry of CD95 apoptosis signaling; 2.2. The TRAIL (Apo2L)system; 3. DEATH RECEPTOR-LIGAND SYSTEMS WITH PRIMARILY IMMUNOSTIMULATORY, PROINFLAMMATORY ACTIVITY; 3.1. The TNF system; 3.1.1. Biochemistry of TNF signal transduction; 3.1.2. TNF and TNF blockers in the clinic; 3.2. The DR3 system; 4. THE DR6 SYSTEM; 5. FUNCTIONAL SPECIALIZATION BY SEQUENTIAL SIGNALING COMPLEX FORMATION IN DEATH RECEPTOR SIGNAL TRANSDUCTION; 6. CONCLUDING REMARKS AND OUTLOOK.
  • SUGGESTED READINGS4 Mitochondria and Cell Death; 1. INTRODUCTION; 2. MITOCHONDRIAL PHYSIOLOGY; 3. THE MITOCHONDRIAL PATHWAY OF APOPTOSIS; 4. MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION; 5. MORPHOLOGICAL CHANGES IN MITOCHONDRIA DURING MOMP; 6. DOWNSTREAM OF MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION; 7. MITOCHONDRIAL PERMEABILITY TRANSITION PORE AND NECROTIC CELL DEATH; 8. COMPARISON OF THE VERTEBRATE AND INVERTEBRATE PATHWAYS OF MITOCHONDRIAL CELL DEATH; 9. CONCLUSIONS; SUGGESTED READINGS; 5 The Control of Mitochondrial Apoptosis by the BCL-2 Family; 1. INTRODUCTION.
  • 2. ACTIVATING APOPTOSIS: BAX AND BAK AND THE ACTIVATOR BH3-ONLY PROTEINS3. INHIBITING APOPTOSIS; 4. INHIBITING THE INHIBITORS; 5. ACTIVATING THE ACTIVATORS
  • CONNECTING THE INSULT TO THE BCL-2 FAMILY; 6. THE BCL-2 FAMILY AND CANCER; SUGGESTED READINGS; 6 Endoplasmic Reticulum Stress Response in Cell Death and Cell Survival; 1. INTRODUCTION; 2. THE ESR IN YEAST; 3. THE ESR IN MAMMALS; 4. THE ESR AND CELL DEATH; 5. THE ESR IN DEVELOPMENT AND TISSUE HOMEOSTASIS; 6. THE ESR IN HUMAN DISEASE; 7. CONCLUSION; 7 Autophagy
  • The Liaison between the Lysosomal System and Cell Death; 1. INTRODUCTION.

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