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Mass spectrometry in sports drug testing : characterization of prohibited substances and doping control analytical assays /
"This book provides a detailed overview about the mass spectrometry of numerous classes of therapeutics and agents relevant to doping control laboratories, the necessity of various analyzers enabling the detection of low- and high molecular weight drugs as well as the discrimination between end...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Hoboken, N.J. :
Wiley,
©2010.
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| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- History of sports drug testing
- Historical attempts of artificial performance enhancement
- Background and rationale of doping controls
- Cheating
- Health issues
- Ethical issues
- Early detection methods: possibilities and limitations of assays without mass spectrometry
- First applications using chemical and biological approaches in horse doping control
- First applications using chemical and biological approaches in horse doping control
- First applications using chemical approaches in human doping control
- Introduction of mass spectrometry to doping control analysis
- First approaches and adverse analytical findings
- Progressino of analytical methods
- Mass spectrometry and the list of prohibited substances and methods of doping
- Criteria for the mass spectrometric identification of prohibited compounds
- Low molecular weight analytes
- High molecular weight analytes
- Modern mass spectrometers in doping controls: advances and disadvantates of available techniques
- Ionization techniques in routine doping controls
- Mass analyzers in routine doping controls
- Structure characterization of low molecular weight target analytes--electron ionization
- Stimulants
- Narcotics
- Anabolic androgenic steroids
- Unsaturated 3-keto-steroids
- a, ß-saturated ketosteroids
- 3-keto-1,4-diene, 3-keto-4,6-diene, and 3-keto-4,9(11)-diene steroids
- Steroid derivatization
- Selective androgen receptor modulators (SARMs)
- 2-quinolinone-based SARMs
- Hydroxybicyclic hydantoin-derived SARMs
- Diuretics
- Thiazide-derived drugs
- Benzoic acid-derived loop diuretics
- Potassium-sparing diuretics
- ß₂-agonists
- ß-receptor blocking agents
- Calcium-channel modulators (RYCALS)
- Carbohydrate-based agents
- Mannitol
- Glycerol
- Hydroxyethl starch and dextran
- Structure characterization of low molecular weight target analytes: electrospray ionization
- Stimulants
- Narcotics
- Anabolic androgenic steroids
- z, ß-saturated 3-keto-steroids
- 3-keto-4-ene and 3keto-1-ene steroids
- 3-keto-1,4-diene steroids
- 3-keto-4,6-diene steroids
- 3-keto-4,9-diene steroids
- 3-keto-4,9,1-triene steroids
- Stanozolol
- Selective androgen receptor modulators (SARMs)
- Arylpropionamide-derived SARMs
- Hydroxybicyclic hydantoin-derived SARMs
- 2-quinolinone-derived SARMs
- Diuretics
- Thiazide-derived drugs
- Benzoic acid-derived loop diuretics
- Potassium-sparing diuretics
- ß₂-agonists
- Calcium-channel modulators (RYCALS)
- Peroxisome-proliferator activated receptor- (PPAR) and adenosine monophosphate activated protein kinase (AMPK) agonists
- Hypoxia-inducible factor (HIF)-stabilizers and sirtuin activators
- HIF-stabilizers
- Sirtuin activators
- ß-receptor blocking agents
- Glucuronic acid and sulfate conjugates of target analytes.
- Structure characterization of high molecular weight target analytes: electrospray ionization
- Human chorionic gonadotrophin (hCG)
- Erythropoietins (EPO)
- Synacthen
- Insulins
- Hemoglobin-based oxygen carriers (HBOCs)
- Human growth hormone (hGH)
- Sermorelin (Geref)
- Insulin-like growth factor-1 (IGF-1)
- Gonadorelin (LHRH)
- Modern mass spectrometry-based analytical assays
- GC-MS and isotope ratio mass spectrometry
- Stimulants/narcotics
- Anabolic androgenic steroids
- Diuretics
- ß₂-agonists and ß-receptor blocking agents
- Carbohydrate-based agents
- LC-MS/MS
- Stimulants/narcotics/ß₂-agonists/ß-receptor blocking agents
- Anabolic androgenic steroids/corticosteroids/hormone antagonists and modulators
- Masking agents (including diuretics)
- Peptide hormones <10kDa including insulins, synacthen, gonadorelin, IGF-1
- Hemoglobin-based oxygen carriers
- Human chorionic gonadotrophin (hCG)
- Limitations and perspectives of mass spectrometry-based procedures in doping control analysis
- Recombinant biomolecules
- Erythropoietin
- Human growth hormone
- Human insulin and IFG-1
- Unknown compounds
- Profiling of urine and/or blood
- Alternative specimens.