Methodological challenges in biomedical HIV prevention trials /

"This IOM committee was formed at the request of the Bill & Melinda Gates Foundation and charged with addressing methodological challenges in late-stage nonvaccine biomedical HIV prevention trials with a specific focus on microbicide and pre-exposure prophylaxis trials."

Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: Institute of Medicine (U.S.). Committee on the Methodological Challenges in HIV Prevention Trials
Other Authors: Gable, Alicia, Lagakos, Stephen W.
Format: Electronic eBook
Language:Inglés
Published: Washington, D.C. : National Academies Press, ©2008.
Subjects:
AIDS (Disease) > Prevention.
HIV Infections > prevention & control
Clinical Trials as Topic
Program Evaluation > methods
Anti-Infective Agents > therapeutic use
Anti-Retroviral Agents > therapeutic use
Sida > Prévention.
POLITICAL SCIENCE > Public Policy > Social Security.
POLITICAL SCIENCE > Public Policy > Social Services & Welfare.
AIDS (Disease) > Prevention
Online Access:Texto completo
Table of Contents:
  • Front Matter
  • Reviewers
  • Contents
  • Summary
  • Introduction
  • 1 The Status and Challenges of Biomedical HIV Prevention Trials
  • 2 Basic Design Features: Size, Duration, and Type of Trials, and Choice of Control Group
  • 3 Design Considerations: Risk-Reduction Counseling
  • 4 Design Considerations: Pregnancy
  • 5 Design Considerations: Adherence
  • 6 Design Considerations: Recruitment and Retention
  • 7 Site Preparedness
  • 8 Estimating HIV Incidence
  • 9 Interim Monitoring and Analysis of Results
  • 10 Alternative Designs
  • Appendixes
  • Appendix A: Public Committee Meeting AgendasAppendix B: Acronyms
  • Appendix C: Supporting Materials for Chapter 2
  • Appendix D: Methods for Analyzing Adherence
  • Appendix E: Committee Biographies

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