Group-Sequential Clinical Trials with Multiple Co-Objectives

This book focuses on group sequential methods for clinical trials with co-primary endpoints based on the decision-making frameworks for: (1) rejecting the null hypothesis (stopping for efficacy), (2) rejecting the alternative hypothesis (stopping for futility), and (3) rejecting the null or alternat...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autores principales: Hamasaki, Toshimitsu (Autor), Asakura, Koko (Autor), Evans, Scott R. (Autor), Ochiai, Toshimitsu (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Tokyo : Springer Japan : Imprint: Springer, 2016.
Edición:1st ed. 2016.
Colección:JSS Research Series in Statistics,
Temas:
Statistics .
Biometry.
Social sciences-Statistical methods.
Statistical Theory and Methods.
Biostatistics.
Statistics in Social Sciences, Humanities, Law, Education, Behavorial Sciences, Public Policy.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • 1. Introduction
  • 2. Early Stopping for Efficacy in Clinical Trials with multiple co-primary endpoints
  • 3. Sample size recalculation based on observed effects at interim
  • 4. Early stopping for futility in Clinical Trials with multiple co-primary endpoints
  • 5. Early stopping for futility or Efficacy in Clinical Trials with multiple co-primary endpoints
  • 6. Clinical Trials with multiple primary endpoints
  • 7. Group-sequential designs for three-arm noninferiority clinical trials
  • 8. Further development: topics not covered in this book.

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