The Immune Synapse as a Novel Target for Therapy

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The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell-APC junction. It plays an essential role in the control and nature...

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Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: SpringerLink (Online service)
Other Authors: Graca, Luis (Editor)
Format: Electronic eBook
Language:Inglés
Published: Basel : Birkhäuser Basel : Imprint: Birkhäuser, 2008.
Edition:1st ed. 2008.
Series:Progress in Inflammation Research,
Subjects:
Immunology.
Diseases.
Cytology.
Medicine > Research.
Biology > Research.
Pharmacology.
Allergy.
Cell Biology.
Biomedical Research.
Allergology.
Online Access:Texto Completo
Table of Contents:
  • The immune synapse and T cell activation: regulation by chemokines
  • The induction of regulatory T cells by targeting the immune synapse
  • Infiltrating the immunological synapse: prospects for the use of altered peptide ligands for the treatment of immune pathology
  • Targeting CD4 for the induction of dominant tolerance
  • Anti-CD3: from T cell depletion to tolerance induction
  • Immune modulation by CD40L blockade
  • CTLA-4-immunoglobulin and indoleamine 2,3-dioxygenase in dominant tolerance
  • Adhesion molecules as therapeutic targets
  • E3 ubiquitin ligases and immune tolerance: Targeting the immune synapse from within?
  • FOXP3 biochemistry will lead to novel drug approaches for vaccines and diseases that lack suppressor T cells
  • Transforming growth factor-?: From its effect in T cell activation to a role in dominant tolerance
  • From mice to men: the challenges of developing tolerance-inducing biological drugs for the clinic.

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