Chemical Biology of Nucleic Acids Fundamentals and Clinical Applications /

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their anal...

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Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: SpringerLink (Online service)
Other Authors: Erdmann, Volker A. (Editor), Markiewicz, Wojciech T. (Editor), Barciszewski, Jan (Editor)
Format: Electronic eBook
Language:Inglés
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
Edition:1st ed. 2014.
Series:RNA Technologies,
Subjects:
Biomaterials.
Nucleic acids.
Medicine > Research.
Biology > Research.
Medical genetics.
Nucleic Acid.
Biomedical Research.
Medical Genetics.
Online Access:Texto Completo
Table of Contents:
  • RNA as Major Components in Chemical Evolvable Systems
  • How the Early Genetic Code Was Established? - Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems
  • Isomerization of RNA Phosphodiester Linkages
  • Effects of Ionic Liquid and Liposomes on the Structure, Stability and Function of Nucleic Acids
  • Oxidative Damage on RNA Nucleobases
  • Use of FRET to Study Dynamics of DNA Replication
  • Design, Characterization and Application of Imidazopyridopyrimidine:Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds
  • Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies
  • Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids
  • Sequence Selective Recognition of Double-Stranded RNA
  • Determining Transient Nucleic Acid Structures by NMR
  • Diastereomer-Specific Repertoire of 7'R- or 7'S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties
  • Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms
  • Progress in Chemically Modified Nucleic Acid Aptamers
  • Aptamers as Molecular Smugglers
  • Biochemical Aspects of Subcellular RNA Transport and Localization
  • Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications
  • Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology
  • Targeted Editing of Therapeutic Genes Using DNA-Based Transcriptional Activators: Scope and Challenges
  • Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression
  • Site Directed Spin Labelling of RNA for Distance Measurements by EPR
  • Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells
  • Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches
  • DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics
  • Peptides Targeting G-Quadruplex Structures
  • Synthesis of Site-Specifically Modified Long-Mer RNAs
  • Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs
  • mRNA and snRNA Cap Analogs: Synthesis and Applications
  • Innovative Chemistry for Synthesis of Regular RNA, 5'-Triphosphate RNA or 5'-Capped RNA.

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