Molecular Mechanisms in Legionella Pathogenesis

Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparati...

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Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: SpringerLink (Online service)
Other Authors: Hilbi, Hubert (Editor)
Format: Electronic eBook
Language:Inglés
Published: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2014.
Edition:1st ed. 2014.
Series:Current Topics in Microbiology and Immunology, 376
Subjects:
Medical microbiology.
Diseases.
Medicine > Research.
Biology > Research.
Immunology.
Bacteria.
Medical Microbiology.
Biomedical Research.
Online Access:Texto Completo
Table of Contents:
  • From amoeba to macrophages: exploring the molecular mechanisms of Legionella infection in both hosts
  • The Legionella pneumophila two-component regulatory systems that participate in the regulation of Icm/Dot effectors
  • Facets of small RNA-mediated regulation in Legionella pneumophila
  • Type II secretion and Legionella virulence
  • Effector translocation by the Legionella Icm/Dot type IV secretion system
  • Modulation of small GTPases by Legionella
  • Host lipidation: A mechanism for spatial regulation of Legionella effectors
  • Phosphoinositides and the Legionella pathogen vacuole
  • Legionella phospholipases implicated in virulence
  • Cytotoxic glucosyltransferases of Legionella pneumophila
  • Modulation of the ubiquitination machinery by Legionella
  • Host signal transduction and protein kinases implicated in Legionella infection
  • Mouse models of Legionnaires´ disease.

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