Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R Order-Restricted Analysis of Microarray Data /

This book focuses on the analysis of dose-response microarray data in pharmaceutical setting, the goal being to cover this important topic for early drug development and to provide user-friendly R packages that can be used to analyze dose-response microarray data. It is intended for biostatisticians...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Lin, Dan (Editor ), Shkedy, Ziv (Editor ), Yekutieli, Daniel (Editor ), Amaratunga, Dhammika (Editor ), Bijnens, Luc (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2012.
Edición:1st ed. 2012.
Colección:Use R!,
Temas:
Statistics .
Mathematical statistics-Data processing.
Pharmaceutical chemistry.
Biometry.
Bioinformatics.
Statistics.
Statistics and Computing.
Pharmaceutics.
Biostatistics.
Computational and Systems Biology.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Introduction
  • Part I: Dose-response Modeling: An Introduction
  • Estimation Under Order Restrictions
  • The Likelihood Ratio Test
  • Part II: Dose-response Microarray Experiments
  • Functional Genomic Dose-response Experiments
  • Adjustment for Multiplicity
  • Test for Trend
  • Order Restricted Bisclusters
  • Classification of Trends in Dose-response Microarray Experiments Using Information Theory Selection Methods
  • Multiple Contrast Test
  • Confidence Intervals for the Selected Parameters
  • Case Study Using GUI in R: Gene Expression Analysis After Acute Treatment With Antipsychotics.

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