Phosphodiesterases as Drug Targets

Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Francis, Sharron H. (Editor ), Conti, Marco (Editor ), Houslay, Miles D. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
Edición:1st ed. 2011.
Colección:Handbook of Experimental Pharmacology, 204
Temas:
Pharmacology.
Medicinal chemistry.
Proteins.
Enzymology.
Post-translational modification.
Cytology.
Medicinal Chemistry.
Post-translational Modifications.
Cell Biology.
Acceso en línea:Texto Completo
Descripción
Sumario:Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
Descripción Física:XVIII, 522 p. online resource.
ISBN:9783642179693
ISSN:1865-0325 ;

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