Drug Transporters

It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are mos...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Fromm, Martin F. (Editor ), Kim, Richard B. (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Berlin, Heidelberg : Springer Berlin Heidelberg : Imprint: Springer, 2011.
Edición:1st ed. 2011.
Colección:Handbook of Experimental Pharmacology, 201
Temas:
Pharmacology.
Pharmaceutical chemistry.
Human physiology.
Medical microbiology.
Internal medicine.
Nephrology.
Pharmaceutics.
Human Physiology.
Medical Microbiology.
Internal Medicine.
Acceso en línea:Texto Completo

MARC

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245 1 0 |a Drug Transporters  |h [electronic resource] /  |c edited by Martin F. Fromm, Richard B. Kim. 
250 |a 1st ed. 2011. 
264 1 |a Berlin, Heidelberg :  |b Springer Berlin Heidelberg :  |b Imprint: Springer,  |c 2011. 
300 |a X, 454 p.  |b online resource. 
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490 1 |a Handbook of Experimental Pharmacology,  |x 1865-0325 ;  |v 201 
505 0 |a From the contents -- Preface -- Organic anion transporting polypeptides (OATPs); In vitro and in vivo evidence for the importance of organic anion transporters (OATs) in drug therapy; In vitro and in vivo evidence for the importance of organic cation transporters (OCTs, MATEs) in drug therapy; Intestinal bile salt transporters (ASBT and OST alpha/beta); hepatic bile salt transporters (NTCP and BSEP); Importance of P-glycoprotein for drug-drug interactions; Importance of the multidrug resistance protein (MRP) family for pathophysiology and drug therapy; Importance of breast cancer resistance protein transporters (BCRP); Molecular mechanisms of drug transporters regulation; In vivo probes of drug transport. 
520 |a It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies. 
650 0 |a Pharmacology. 
650 0 |a Pharmaceutical chemistry. 
650 0 |a Human physiology. 
650 0 |a Medical microbiology. 
650 0 |a Internal medicine. 
650 0 |a Nephrology. 
650 1 4 |a Pharmacology. 
650 2 4 |a Pharmaceutics. 
650 2 4 |a Human Physiology. 
650 2 4 |a Medical Microbiology. 
650 2 4 |a Internal Medicine. 
650 2 4 |a Nephrology. 
700 1 |a Fromm, Martin F.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
700 1 |a Kim, Richard B.  |e editor.  |4 edt  |4 http://id.loc.gov/vocabulary/relators/edt 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer Nature eBook 
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830 0 |a Handbook of Experimental Pharmacology,  |x 1865-0325 ;  |v 201 
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950 |a Biomedical and Life Sciences (SpringerNature-11642) 
950 |a Biomedical and Life Sciences (R0) (SpringerNature-43708) 

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