PI3K-mTOR in Cancer and Cancer Therapy

In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhe...

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Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: SpringerLink (Online service)
Other Authors: Dey, Nandini (Editor), De, Pradip (Editor), Leyland-Jones, Brian (Editor)
Format: Electronic eBook
Language:Inglés
Published: Cham : Springer International Publishing : Imprint: Humana, 2016.
Edition:1st ed. 2016.
Series:Cancer Drug Discovery and Development,
Subjects:
Cancer.
Medicine-Research.
Biology-Research.
Medical microbiology.
Cancer Biology.
Biomedical Research.
Medical Microbiology.
Online Access:Texto Completo
Table of Contents:
  • PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics
  • Part 1: PI3K-mTOR Pathway in Cancers
  • The mTOR Complexes in Cancer Cell Metabolism
  • PI3K-AKT-mTOR Pathway Co-operates with the DNA Damage Repair Pathway: Carcinogenesis in Triple Negative Breast Cancers and Beyond
  • The AKT-mTOR Signaling Pathway for Drug Response Prediction and Prognostic Signatures
  • Resistance to PI3K Pathway Inhibition
  • Part 2: PI3K-mTOR Pathway in Cancer Medicine
  • Combination Therapies Targeting the PI3K/AKT/mTOR Pathways
  • Phospho-Inositol-3-Kinase Activity and Dysregulation in Pediatric Leukemia and Lymphoma
  • HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination Therapies
  • The PI3K-mTOR Pathway in Prostate Cancer: Biological Significance and Therapeutic Opportunities.

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