PARP Inhibitors for Cancer Therapy

PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP-poly ADP ribose polymerase-in cancer therapy. The volume covers the history of the discovery of PARP and its role in DNA repair. Additionally, it describes the discovery of the PARP family, and includes a discus...

Full description

Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: SpringerLink (Online service)
Other Authors: Curtin, Nicola J. (Editor), Sharma, Ricky A. (Editor)
Format: Electronic eBook
Language:Inglés
Published: Cham : Springer International Publishing : Imprint: Humana, 2015.
Edition:1st ed. 2015.
Series:Cancer Drug Discovery and Development,
Subjects:
Cancer.
Medical microbiology.
Medicine-Research.
Biology-Research.
Cancer Biology.
Medical Microbiology.
Biomedical Research.
Online Access:Texto Completo
Table of Contents:
  • History of the discovery of poly (ADP-ribose)
  • Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members
  • The role of PARPs in DNA Strand Break Repair
  • TIPs: Tankyrase Interacting Proteins
  • PARP and Carcinogenesis
  • Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity
  • Overview of PARP Inhibitor Design and Optimization
  • Structure Based Design of PARP Inhibitors
  • Preclinical chemosensitization by PARP inhibitors
  • Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents
  • Radiosensitisation by poly(ADP-ribose) polymerase inhibition
  • The vasoactivity of PARP inhibitors
  • Synthetic lethality with Homologous Recombination Repair defects
  • Targeting tumour hypoxia with PARP Inhibitors: Contextual synthetic lethality
  • Other determinants of sensitivity
  • Synthetic sickness with molecularly targeted agents against the EGFR pathway
  • Disruption of DNA repair by cell cycle and transcriptional CDK inhibition
  • Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations
  • PARP inhibitor resistance - what is beyond BRCA1 or BRCA2 restoration
  • Introduction to PARPi clinical trials and future directions
  • Clinical trials investigating PARP inhibitors as single agents
  • Clinical trials of PARP inhibitors with chemotherapy
  • Combination of PARP inhibitors with clinical radiotherapy
  • Biomarkers for PARP Inhibitors.

Similar Items