How Free Cationic Polymer Chains Promote Gene Transfection

In this PhD thesis, Yue Yanan addresses a long-overlooked and critical question in the development of non-viral vectors for gene delivery. The author determines that those uncomplexed and cationic polymer chains free in the solution mixture of polymer and DNA facilitate and promote gene transfection...

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Bibliographic Details
Call Number:Libro Electrónico
Main Author: Yanan, Yue (Author)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:Inglés
Published: Cham : Springer International Publishing : Imprint: Springer, 2013.
Edition:1st ed. 2013.
Series:Springer Theses, Recognizing Outstanding Ph.D. Research,
Subjects:
Polymers.
Chemistry, Organic.
Biomaterials.
Nucleic acids.
Organic Chemistry.
Nucleic Acid.
Online Access:Texto Completo
Table of Contents:
  • Introduction and background
  • Revisiting complexation between DNA and polyethylenimine: the effect of uncomplexed chains free in the solution mixture on gene transfection
  • Revisiting complexation between DNA and polyethylenimine: the effect of length of free polycationic chains on gene transfection
  • Quantitative comparison of endocytosis and intracellular trafficking of DNA/polymer complexes in the absence/presence of free polycationic chains.

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