The Epothilones: An Outstanding Family of Anti-Tumor Agents From Soil to the Clinic /

Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulim...

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Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: SpringerLink (Online service)
Other Authors: Mulzer, Johann H. (Editor)
Format: Electronic eBook
Language:Inglés
Published: Vienna : Springer Vienna : Imprint: Springer, 2009.
Edition:1st ed. 2009.
Series:Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products ; 90
Subjects:
Chemistry, Organic.
Medicinal chemistry.
Biotechnology.
Chemistry, Technical.
Bioorganic chemistry.
Organic Chemistry.
Medicinal Chemistry.
Industrial Chemistry.
Bioorganic Chemistry.
Online Access:Texto Completo
Table of Contents:
  • General Aspects
  • Biosynthesis and Heterologous Production of Epothilones
  • Total Synthesis of Epothilones A-F
  • Semisynthetic Derivatives of Epothilones
  • Preclinical Pharmacology and Structure-Activity Studies of Epothilones
  • Clinical Studies with Epothilones.

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