Transporters in Drug Development Discovery, Optimization, Clinical Study and Regulation /

Transporters in Drug Development examines how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the inte...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Autor Corporativo: SpringerLink (Online service)
Otros Autores: Sugiyama, Yuichi (Editor ), Steffansen, Bente (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: New York, NY : Springer New York : Imprint: Springer, 2013.
Edición:1st ed. 2013.
Colección:AAPS Advances in the Pharmaceutical Sciences Series, 7
Temas:
Pharmaceutical chemistry.
Medicine-Research.
Biology-Research.
Pharmaceutics.
Biomedical Research.
Acceso en línea:Texto Completo
Tabla de Contenidos:
  • Membrane Transporters in ADME
  • In Vitro Characterization of Transporter Mediated Permeability
  • In Vitro Characterization of Interactions with Drug Transporting Proteins
  • In Vivo Characterization of Interactions on Transporters
  • Application of Targeted Proteomics in ADME for IVIVE
  • Prediction of Transporter Mediated Drug-Drug Interaction from In Vitro Data
  • Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)
  • Analysis of Intestinal Transporters
  • Analysis of Hepatic Transport Proteins
  • Analysis of Renal Transporters
  • The Role of Transporters During Drug Development: Regulatory Science Perspective from the FDA
  • Industrial Evaluation of Drug Transporters in ADME.

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