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Resistance to Immunotherapeutic Antibodies in Cancer Strategies to Overcome Resistance /
The current application of antibody-meditated targeted therapy against cancer has resulted in significant objective clinical responses, prolongation of survival and even cures. More than 20 mAbs have been approved for human use targeting a range of different cancers. However, a major drawback of mAb...
| Call Number: | Libro Electrónico |
|---|---|
| Corporate Author: | |
| Other Authors: | |
| Format: | Electronic eBook |
| Language: | Inglés |
| Published: |
New York, NY :
Springer New York : Imprint: Springer,
2013.
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| Edition: | 1st ed. 2013. |
| Series: | Resistance to Targeted Anti-Cancer Therapeutics,
2 |
| Subjects: | |
| Online Access: | Texto Completo |
Table of Contents:
- Preface
- Introduction and generation of chimeric and humanized mAbs
- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment
- Antibodies directed against different major cancers: Effects when used alone or in combination with drugs
- Mechanisms of antibodies-mediated responses, in vitro and in vivo
- Molecular Pathways
- Molecular Signatures
- Identification of resistance targets for intervention
- Various chemicals that can sensitize resistant tumor cells
- Other mAbs
- Proteasome inhibitors
- Divalent mAbs
- Antibodies coupled to chemical inhibitors
- Antibodies coupled to cytokines
- Nanoparticles with mAbs
- Index.