The Fundamentals of Modern Statistical Genetics

This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel's first experiments to genome-wide association studies, the book describes how genetic information can be inco...

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Bibliographic Details
Call Number:Libro Electrónico
Main Authors: Laird, Nan M. (Author), Lange, Christoph (Author)
Corporate Author: SpringerLink (Online service)
Format: Electronic eBook
Language:Inglés
Published: New York, NY : Springer New York : Imprint: Springer, 2011.
Edition:1st ed. 2011.
Series:Statistics for Biology and Health,
Subjects:
Biometry.
Medical genetics.
Biometric identification.
Epidemiology.
Biostatistics.
Medical Genetics.
Biometrics.
Online Access:Texto Completo
Table of Contents:
  • Introduction to statistical genetics and background in molecular genetics
  • Principles of inheritance: mendel's laws and genetic models
  • Some basic concepts from population genetics
  • Aggregation, heritability and segregation analysis: modeling genetic inheritance without genetic data
  • The general concepts of gene mapping: Linkage, association, linkage disequilibrium and marker maps
  • Basic concepts of linkage analysis
  • The basics of genetic association analysis
  • Population substructure in association studies
  • Association analysis in family designs
  • Advanced topics
  • Genome wide assocation studies
  • Looking toward the future.

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