Cellular Senescence and Tumor Suppression

Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, sho...

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Bibliographic Details
Call Number:Libro Electrónico
Corporate Author: SpringerLink (Online service)
Other Authors: Adams, Peter D. (Editor), Sedivy, John M. (Editor)
Format: Electronic eBook
Language:Inglés
Published: New York, NY : Springer New York : Imprint: Springer, 2010.
Edition:1st ed. 2010.
Subjects:
Cancer.
Medical genetics.
Pharmacology.
Cancer Biology.
Medical Genetics.
Online Access:Texto Completo
Table of Contents:
  • Senescence signals
  • Telomere Biology and Biochemistry
  • Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance
  • Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses
  • Stress-Induced Senescence
  • The senescent phenotype
  • The Secretome of Senescent Cells
  • Chromatin Structure in Senescent Cells
  • A Comparison of Senescence in Mouse and Human Cells
  • The physiological consequences of senescence
  • Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism
  • Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging
  • Mining Cellular Senescence for Drug Targets.

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