Cargando…
The p53 Tumor Suppressor Pathway and Cancer
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a tran...
| Clasificación: | Libro Electrónico |
|---|---|
| Autor Corporativo: | |
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
New York, NY :
Springer US : Imprint: Springer,
2005.
|
| Edición: | 1st ed. 2005. |
| Colección: | Protein Reviews ;
2 |
| Temas: | |
| Acceso en línea: | Texto Completo |
Tabla de Contenidos:
- The p53 Network
- The Three-Dimensional Structure of p53
- Transcriptional Activation by p53: Mechanisms and Targeted Genes
- Transcriptional Repression by the p53 Tumor Suppressor Protein
- Posttranslational Modifications of p53: Upstream Signaling Pathways
- p53 in Human Cancer - Somatic and Inherited Mutations and Mutation-independent Mechanisms
- MDM2 and MDMX Regulators of p53 Activity
- p53 Family Members: p63 and p73
- The Oncogenic Activity of p53 Mutants
- Therapeutic Strategies Based on Pharmacological Modulation of p53 Pathway.