Translational Neuroscience : Toward New Therapies /

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Today, translational neuroscience faces significant challenges. Available therapies to treat brain and nervous system disorders are extremely limited and dated, and further development has effectively ceased. Disinvestment by the private sector occurred just as promising new technologies in genomics...

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Detalles Bibliográficos
Otros Autores: Hyman, Steven E., Nikolich, Karoly
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : The MIT Press, [2015]
Colección:Book collections on Project MUSE.
Temas:
Neurosciences > Research.
Nervous system > Diseases.
Drug development.
MEDICAL > Internal Medicine.
MEDICAL > Evidence-Based Medicine.
MEDICAL > Diseases.
MEDICAL > Clinical Medicine.
HEALTH & FITNESS > Diseases > General.
Medicaments > Developpement.
Systeme nerveux > Maladies.
Neurosciences > Recherche.
Nervous System Diseases
Models, Animal
Translational Research, Biomedical
Nervous System Diseases > therapy
Actes de congres.
Conference papers and proceedings.
Congress
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro; Contents; The Ernst Strüngmann Forum; List of Contributors; 1
  • Introduction; Neurodevelopmental Disorders: A New Beginning; Neurodegenerative Diseases:Coming Unstuck; New Tools to Drive Future Therapies; From Cellular and Animal Models to Patients; Epilogue; Bibliography; Subject Index; 2
  • What Do We Know about Early Onset Neurodevelopmental Disorders?; 3
  • Psychotic Disorders and the Neurodevelopmental Continuum; 4
  • Neurodevelopmental Disorders; 5
  • Neurodegenerative Diseases; 6
  • Preclinical and Clinical Understanding; 7
  • Neurodegenerative Diseases.
  • 8
  • How Might We Get from Genes to Circuits to Disease?9
  • How Do We Define and Modulate Circuits in Animals That Are Relevant to Pathophysiology in Humans?; 10
  • Pathophysiological Toolkit; 11
  • Using a Stem Cell-Based Approach to Model Neurodegenerative Disease; 12
  • From Rodent Behavioral Models to Human Disorders; 13
  • Bridging the Gap between Patients and Models; 14
  • The Revolution Has Begun.

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