The Na+, K+ Pumps Keep Us Going /

Detalles Bibliográficos
Autor principal: Clausen, Torben (Autor)
Autor Corporativo: ProQuest (Firm)
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Aarhus, Denmark : Aarhus University Press, 2016.
Colección:Book collections on Project MUSE.
Temas:
Sodium/potassium ATPase.
Sodium > Physiological transport.
Potassium > Physiological transport.
Potassium > Transport physiologique.
Sodium > Transport physiologique.
Pompe à sodium.
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • The Na+, K+ pump and its discovery
  • The transport and distribution of Na+ and K+ in skeletal muscle and how they are quantified
  • Rapid passive fluxes of Na+ and K+ start muscle contraction and set a limit to excitability
  • The definition, structure and function of the Na+, K+-pump
  • The synthesis and localization of the Na+, K+ pumps in skeletal muscle
  • Measurements of the content of [3H]ouabain binding sites indicate that in skeletal muscle, the major part of these binding sites of the Na+, K+ pumps are localized on the outer surface of sarcolemma and in the t-tubules
  • The content of Na+, K+ pumps in skeletal muscles and how it can be quantified
  • Muscle contractions, Na+, K+ transport and sodium potassium fatigue
  • The rate of [³H]ouabain binding to sarcolemma can be quantified and what information may this provide?
  • Measurements of [3H]ouabain binding to other cell types and preparations
  • Acute and long-term regulation of Na+, K+ pumps in skeletal muscle
  • Catecholamines and caffeine
  • Peptide hormones stimulating the Na+, K+ pumps
  • Insulin-like growth Factore-I (IGF-I)
  • CGRP and other calcitonins
  • Amylin, related peptides, and other stimuli for the Na+, K+ -pumps
  • The importance of Na+-influx in causing depolarization and muscle fatigue
  • Effect of varying Na+, K+-pump stimulating agents on intracellular Na+ in rat soleus muscles and how this may compensate functional defects caused by plasma membrane leakage
  • Long-Term regulation of Na+, K+ pump content
  • Training, inactivity and denervation
  • Muscular dystrophy and McArdle disease
  • Hyperkalemic periodic paralysis in horses, human subjects and mutant mice with a similar geneti anomaly
  • K+ deficiency and K+ restoration
  • Thyroid hormones ans starvation
  • Thermogenic actions of thyroid hormones and malignant hyperthermia (MH)
  • Diabetes
  • Steroid hormones, glucocorticoids, aldosterone
  • Major conclusions and general perspectives.

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