Progress in molecular biology and translational science. volume 199, Stem cell in medicine /

Stem Cells in Medicine, Volume 199 in the Progress in Molecular Biology and Translational Science series, provides the most topical and informative research in the field of stem cells. Sections in this new release update on an Introduction to stem cells, Stem cell engineering, Xeno-free culture and...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Higuchi, Akon (Editor ), Zhou, Yinghong (Editor ), Chiou, Shih-Hwa (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, an imprint of Elsevier, 2023.
Edición:First edition.
Colección:Progress in molecular biology and translational science ; volume 199
Temas:
Stem cells.
Stem cells > Therapeutic use.
Stem Cells
Cellules souches.
Cellules souches > Emploi en th�erapeutique.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Fundamental of hPSCs for medical
  • Chapter One: Introduction to stem cells
  • Abstract
  • 1 Introduction
  • 2 Fundamentals of stem cell research
  • 3 hPSCs
  • 4 Somatic cell reprogramming and induced pluripotent stem cells
  • 5 Adult stem cells
  • 6 Conclusion
  • Acknowledgment
  • References
  • Chapter Two: Engineered adult stem cells: Current clinical trials status of disease treatment
  • Abstract
  • 1 Introduction
  • 2 Cell source and applications of adult MSCs and HSCs
  • 3 Engineering techniques for adult MSCs and HSCs
  • 4 CRISPR/Cas9 system and strategies to overcome challenges
  • 5 Current clinical trial status of engineered MSCs, HSCs and EVs
  • 6 Future perspectives of personalised medicine using engineered stem cells
  • 7 Concluding remarks
  • References
  • Chapter Three: Xeno-free culture and proliferation of hPSCs on 2D biomaterials
  • Abstract
  • 1 Introduction
  • 2 Pluripotency assay of hPSCs
  • 3 Physical cues of cell culture materials direct the pluripotency and differentiation of hPSCs
  • 4 Two-dimensional (2D) cultivation of hPSCs on ECM-coated surfaces
  • 5 hPSC cultivation on peptide-immobilized surfaces
  • 6 hPSC cultivation on recombinant E-cadherin matrices
  • 7 hPSC cultivation on polysaccharide-immobilized biomaterials
  • 8 hPSC cultivation on a synthetic polymer surface
  • 9 Conclusion and future perspectives
  • Acknowledgments
  • References
  • Chapter Four: Stem cell culture and differentiation in 3-D scaffolds
  • Abstract
  • 1 Introduction
  • 2 The 3-D cultivation of hPS cells on microcarriers
  • 3 The 3-D culture of hPS cells entrapped in hydrogels (microcapsules)
  • 4 Differentiation of hPS cells into hepatocytes on 3-D cultivation
  • 5 Conclusion and future perspectives
  • Acknowledgments
  • References
  • Clinical application.
  • Chapter Five: Current trends and promising clinical utility of IPSC-derived MSC (iMSC)
  • Abstract
  • 1 Introduction
  • 2 Generation of iMSCs from iPSC
  • 3 General characteristics of iMSC in comparison to primary MSC
  • 4 Properties of iMSC that may cater to large scale production of homogenous clinical grade MSCs
  • 5 Applications of iMSC
  • 6 Scaling up
  • 7 Conclusion
  • References
  • Chapter Six: Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells
  • Abstract
  • 1 Introduction
  • 2 Materials and methods
  • 3 Results
  • 4 Discussion
  • 5 Ethics approval and consent to participate
  • References
  • Chapter Seven: Cardiac cell sheet engineering for regenerative medicine and tissue modeling
  • Abstract
  • 1 Introduction
  • 2 Cell sheet engineering
  • 3 Development of human cardiac tissue for regenerative medicine
  • 4 Tissue function evaluation technologies
  • 5 For the improvement of human cardiac tissue function
  • 6 Tissue models for disease research
  • Acknowledgment
  • References
  • Chapter Eight: Mesenchymal stem cells in osteoarthritis: The need for translation into clinical therapy
  • Abstract
  • Abbreviations
  • 1 Properties of MSCs for regenerative medicine
  • 2 Functional effects of mesenchymal stem cells on OA
  • 3 MSCs therapy for human osteoarthritis
  • 4 MSCs therapy for OA in small animal model
  • 5 MSCs therapy for OA in large animal model
  • 6 Mechanisms of action of mesenchymal stem cells in cartilage repair
  • 7 MSCs derived factors in cartilage repair
  • 8 MSCs derived extracellular vesicles in cartilage repair
  • 9 Future, challenges and controversies
  • References
  • Chapter Nine: hPSC-derived RPE transplantation for the treatment of macular degeneration
  • Abstract
  • 1 Introduction
  • 2 Differentiation methods of hPSC-derived RPE
  • 3 Characterization of hPSC-derived RPE.
  • 4 Clinical outcomes of hPSC-derived RPE transplantation
  • 5 Conclusion and future perspective
  • Acknowledgment
  • References
  • Chapter Ten: Universal and hypoimmunogenic pluripotent stem cells for clinical usage
  • Abstract
  • 1 Introduction
  • 2 Preparation of universal (hypoimmunogenic) hPS cells
  • 3 Preparation of universal hPS cells using B2MG knockout
  • 4 Preparation of universal hPS cells by knocking down or knocking out HLA-A, -B, and/or -C
  • 5 Preparation of HLA-homozygous cells by genome editing techniques
  • 6 Universal hPS cell generation by knocking in several specific genes
  • 7 Universal hPSC generation from particular MSCs with immunomodulatory potential and culturing on specific extracellular matrix
  • 8 Universal hPS cell generation without gene modification
  • 9 Conclusion and future perspectives
  • Acknowledgment
  • References
  • Chapter Eleven: Clinical usage of dental stem cells and their derived extracellular vesicles
  • Abstract
  • 1 Introduction
  • 2 Stem cells of dental origin
  • 3 Preclinical and clinical applications of DSCs
  • 4 DSC-derived EVs and their clinical implications
  • 5 Conclusive remarks and future perspective
  • References
  • Chapter Twelve: Vascularization of cutaneous wounds by stem cells
  • Abstract
  • 1 Introduction
  • 2 Endothelial progenitor cells
  • 3 Induced pluripotent stem cells
  • 4 Mesenchymal stem/stromal cells
  • 5 Conclusions
  • References
  • Chapter Thirteen: Application of IPSC and M|ller glia derivatives in retinal degenerative diseases
  • Abstract
  • 1 Regeneration of M|ller glial cells
  • 2 Transplanted M|ller glial cells promote neuronal repair
  • 3 Proliferation and reprogramming of M|ller glial cells promoted by exogenous stem cell transplantation can be used for the experimental treatment of retinal nerve regeneration.
  • 4 Transplantation of M|ller glial cell-derived neurons in an animal model of retinal degeneration
  • 5 The application of human pluripotent stem cells and M|ller glial cells in the treatment of glaucoma
  • 6 The application of human pluripotent stem cells and M|ller glial cells in the treatment of retinitis pigmentosa
  • References
  • Chapter Fourteen: Pluripotent stem cells as a therapy for type 1 diabetes
  • Abstract
  • 1 Current status of T1D
  • 2 Pancreatic islet therapy is a good alternative to subcutaneous insulin administration
  • 3 Pluripotent stem cell derived islets are a potential alternative to pancreatic islets
  • 4 Clinical trials with stem cell derived � cell precursors
  • 5 Clinical trial with stem cell derived beta cells
  • 6 Immunoisolatory devices to prevent allograft and autoimmune rejection
  • 7 Conclusion
  • References
  • Chapter Fifteen: Stem cell challenges and opportunities
  • Abstract
  • 1 Introduction
  • 2 Materials and methods
  • 3 Results
  • 4 Discussion
  • Acknowledgments
  • References
  • Index.

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