Dihydropyrimidinones as potent anticancer agents : medicinal chemistry perspective /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Bhat, Mashooq Ahmad (Editor ), Rehman. Muneeb U. (Editor ), Verma, Amita (Editor )
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam, Netherlands ; Cambridge, MA : Elsevier, [2023]
Temas:
Antineoplastic agents > Therapeutic use.
Dihydropyridine > Therapeutic use.
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Front Cover
  • Dihydropyrimidinones as Potent Anticancer Agents
  • Copyright Page
  • Contents
  • List of contributors
  • 1 Introduction of dihydropyrimidinones: a medicinal chemistry perspective
  • 1.1 Introduction
  • 1.2 History
  • 1.3 Separation of isomers
  • 1.4 Synthesis
  • 1.4.1 Chemistry and biological activities
  • 1.4.2 New derivative: biphenyl dihydropyrimidinone
  • 1.5 Future perspective
  • 1.6 Conclusion
  • References
  • 2 Synthetic strategies of dihydropyrimidinones
  • 2.1 Introduction
  • 2.2 Synthetic strategies for dihydropyrimidinones
  • 2.2.1 Classical methods to synthesize dihydropyrimidinones
  • 2.2.2 Nonclassical methods to synthesize dihydropyrimidinones
  • 2.2.2.1 Microwave-assisted synthesis
  • 2.2.2.2 Ultrasonication-assisted synthesis
  • 2.2.2.3 Synthesis using ionic liquids as catalysts
  • 2.2.2.4 Synthesis using nanomaterial-assisted catalysts
  • 2.2.2.5 Synthesis under green conditions and chiral catalysts
  • 2.2.2.6 Synthesis using miscellaneous strategies
  • 2.3 Conclusion
  • References
  • 3 Biological activities of dihydropyrimidinones
  • 3.1 Introduction
  • 3.1.1 Antiinflammatory activity
  • 4.2 Synthetic strategies
  • 4.3 Pharmacological potential of dihydropyrimidinones
  • 4.3.1 Antifilarial activity
  • 4.3.2 Antitubercular activity
  • 4.3.3 Antihypertensive activity
  • 4.3.4 Antibacterial activity
  • 4.3.5 Anticancer activity
  • 4.3.6 Antiinflammatory activity
  • 4.3.7 Anti-HIV
  • 4.3.8 Analgesic activity
  • 4.3.9 Antifungal activity
  • 4.3.10 Antihyperglycemic activity
  • 4.3.11 Antisevere acute respiratory syndrome activity
  • 4.3.12 Antioxidant activity
  • 4.3.13 Anticonvulsant activity
  • 4.3.14 Anti-Alzheimer's activity
  • 4.3.15 Antihepatitis activity
  • 4.4 Conclusion
  • Acknowledgment
  • Conflict of interest
  • Funding
  • References
  • 5 Dihydropyrimidinones scaffold and potential anticancer targets
  • 5.1 Introduction
  • 5.2 Biological activities
  • 5.2.1 Anticancer properties
  • 5.2.2 Dihydropyrimidin-2(1H)-one (or thione) scaffolds potent against different cancers
  • 5.2.2.1 Diarylpyrazole-ligated dihydropyrimidinones are potent scaffolds against breast cancer
  • 5.2.2.1.1 Dihydropyrimidinone-based scaffolds are effective against breast cancer
  • 5.2.2.1.2 DHPM-based scaffolds block kinesin Eg5

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