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00000cam a22000007i 4500 |
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SCIDIR_on1394114914 |
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OCoLC |
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20231120010751.0 |
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m o d |
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cr cnu---unuuu |
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230820s2023 ne ob 001 0 eng d |
| 040 |
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|a YDX
|b eng
|e rda
|c YDX
|d OPELS
|d EBLCP
|d N$T
|d YDX
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| 019 |
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|a 1394118865
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|a 9780443153044
|q electronic book
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|a 0443153043
|q electronic book
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|z 9780443190940
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|z 0443190941
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|a (OCoLC)1394114914
|z (OCoLC)1394118865
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| 050 |
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4 |
|a RS431.A64
|b D54 2023
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0 |
4 |
|a 616.99/4061
|2 23/eng/20230904
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|a Dihydropyrimidinones as potent anticancer agents :
|b medicinal chemistry perspective /
|c edited by Mashooq Ahmad Bhat, Muneeb U. Rehman, Amita Verma.
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|a Amsterdam, Netherlands ;
|a Cambridge, MA :
|b Elsevier,
|c [2023]
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| 300 |
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|a 1 online resource (xiii, 279 pages)
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| 336 |
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Includes bibliographical references and index.
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|a Front Cover -- Dihydropyrimidinones as Potent Anticancer Agents -- Copyright Page -- Contents -- List of contributors -- 1 Introduction of dihydropyrimidinones: a medicinal chemistry perspective -- 1.1 Introduction -- 1.2 History -- 1.3 Separation of isomers -- 1.4 Synthesis -- 1.4.1 Chemistry and biological activities -- 1.4.2 New derivative: biphenyl dihydropyrimidinone -- 1.5 Future perspective -- 1.6 Conclusion -- References -- 2 Synthetic strategies of dihydropyrimidinones -- 2.1 Introduction -- 2.2 Synthetic strategies for dihydropyrimidinones
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|a 2.2.1 Classical methods to synthesize dihydropyrimidinones -- 2.2.2 Nonclassical methods to synthesize dihydropyrimidinones -- 2.2.2.1 Microwave-assisted synthesis -- 2.2.2.2 Ultrasonication-assisted synthesis -- 2.2.2.3 Synthesis using ionic liquids as catalysts -- 2.2.2.4 Synthesis using nanomaterial-assisted catalysts -- 2.2.2.5 Synthesis under green conditions and chiral catalysts -- 2.2.2.6 Synthesis using miscellaneous strategies -- 2.3 Conclusion -- References -- 3 Biological activities of dihydropyrimidinones -- 3.1 Introduction -- 3.1.1 Antiinflammatory activity
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|a 4.2 Synthetic strategies -- 4.3 Pharmacological potential of dihydropyrimidinones -- 4.3.1 Antifilarial activity -- 4.3.2 Antitubercular activity -- 4.3.3 Antihypertensive activity -- 4.3.4 Antibacterial activity -- 4.3.5 Anticancer activity -- 4.3.6 Antiinflammatory activity -- 4.3.7 Anti-HIV -- 4.3.8 Analgesic activity -- 4.3.9 Antifungal activity -- 4.3.10 Antihyperglycemic activity -- 4.3.11 Antisevere acute respiratory syndrome activity -- 4.3.12 Antioxidant activity -- 4.3.13 Anticonvulsant activity -- 4.3.14 Anti-Alzheimer's activity -- 4.3.15 Antihepatitis activity -- 4.4 Conclusion
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|a Acknowledgment -- Conflict of interest -- Funding -- References -- 5 Dihydropyrimidinones scaffold and potential anticancer targets -- 5.1 Introduction -- 5.2 Biological activities -- 5.2.1 Anticancer properties -- 5.2.2 Dihydropyrimidin-2(1H)-one (or thione) scaffolds potent against different cancers -- 5.2.2.1 Diarylpyrazole-ligated dihydropyrimidinones are potent scaffolds against breast cancer -- 5.2.2.1.1 Dihydropyrimidinone-based scaffolds are effective against breast cancer -- 5.2.2.1.2 DHPM-based scaffolds block kinesin Eg5
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|a Description based on online resource; title from digital title page (viewed on September 21, 2023).
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| 650 |
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|a Antineoplastic agents
|x Therapeutic use.
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| 650 |
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|a Dihydropyridine
|x Therapeutic use.
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| 655 |
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|a Electronic books.
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| 700 |
1 |
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|a Bhat, Mashooq Ahmad,
|e editor.
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| 700 |
1 |
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|a Rehman. Muneeb U.,
|e editor.
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| 700 |
1 |
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|a Verma, Amita,
|e editor.
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| 776 |
0 |
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|i Print version:
|z 9780443153044
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| 776 |
0 |
8 |
|i Print version:
|z 0443190941
|z 9780443190940
|w (OCoLC)1360286365
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| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/book/9780443190940
|z Texto completo
|
