DYSTONIA

Detalles Bibliográficos
Clasificación:Libro Electrónico
Formato: Electrónico eBook
Idioma:Inglés
Publicado: [S.l.] : ELSEVIER ACADEMIC PRESS, 2023.
Colección:International review of neurobiology ; 169
Temas:
Dystonia.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Title page
  • Table of Contents
  • International Review Of Neurobiology: Dystonia
  • International Review Of Neurobiology
  • Copyright
  • Contributors
  • Chapter One: Clinical features of dystonia and the science of classification
  • Abstract
  • 1 Early observations
  • 2 Phenomenology
  • 3 Motor features
  • 4 Diagnosis
  • 5 Classification
  • 6 Current status and beyond
  • References
  • Chapter Two: What can epidemiological studies teach on the pathophysiology of adult-onset isolated dystonia
  • Abstract
  • 1 Introduction
  • 2 Studies of birth sex in AOID: Suggestions for pathophysiology
  • 3 How does age affect phenotype and natural history of AOID
  • 4 Extra-genetic risk factors and mechanisms of AOID
  • 5 Clinical and epidemiological studies of non-motor symptoms in AOID: Implications for pathophysiology
  • 6 Brain-wide mechanisms and network dysfunction: Supporting evidence from epidemiologic data
  • 7 Form-specific mechanisms: Supporting evidence from epidemiologic data
  • 8 Where to go next investigating risk- and course-modifying factors of dystonia Conclusive remarks
  • References
  • Chapter Three: Dystonia genes and their biological pathways
  • Abstract
  • 1 Introduction
  • 2 Concluding remarks and future perspectives
  • References
  • Chapter Four: The functional anatomy of dystonia: Recent developments
  • Abstract
  • 1 Introduction
  • 2 Neuroimaging in idiopathic dystonia
  • 3 Lesion studies
  • 4 Animal studies in dystonia
  • 5 Pathways of dystonia
  • 6 Future directions
  • 7 Conclusions
  • Acknowledgements
  • References
  • Chapter Five: Physiology of dystonia: Human studies
  • Abstract
  • 1 Introduction
  • 2 Inhibition
  • 3 Plasticity
  • 4 Limitations of inhibition and plasticity hypothesis
  • 5 Peripheral contributions and disrupted sensorimotor integration
  • 6 Oscillations in dystonia
  • 7 Conclusions
  • References.
  • Chapter Six: Physiology of Dystonia: Animal Studies
  • Abstract
  • 1 Introduction
  • 2 Genetic mouse models with mutations in dystonia-associated genes that are affected in human patients
  • 3 Spontaneous genetic models with dystonic movements
  • 4 Neural circuit manipulations causing dystonia
  • 5 Pharmacologically-induced dystonia models
  • 6 Other models of induced dystonia
  • 7 Conclusions
  • References
  • Chapter Seven: Advances in targeting neurotransmitter systems in dystonia
  • Abstract
  • 1 Introduction
  • 2 Physiology of the principal brain neurotransmitters
  • 3 Neurotransmitter-targeting pharmacological therapies
  • 4 New evolving genetic therapies targeting neurotransmitter systems
  • 5 Discussion
  • Acknowledgements
  • References
  • Chapter Eight: Experimental pharmacology: Targeting metabolic pathways
  • Abstract
  • 1 Introduction
  • 2 Genetic-metabolic conditions causing dystonia with available disease-specific treatment
  • 3 Trace element metabolism disorders and NBIA disorders
  • 4 Manganese transport disorders
  • 5 Aceruloplasminemia
  • 6 PKAN
  • 7 Energetic metabolism alterations
  • 8 Lysosomal disorders
  • 9 Neurotransmitter defects
  • 10 Channelopathies and synaptopathies
  • 11 Conclusive remarks
  • References
  • Chapter Nine: Adult-onset focal dystonias: To lump or split
  • Abstract
  • 1 Introduction
  • 2 Lumping
  • 3 Splitting
  • 4 Resolving the paradox
  • 5 Conclusions and future prospects
  • References
  • Chapter Ten: Early-onset inherited dystonias versus late-onset idiopathic dystonias: Same or different biological mechanisms
  • Abstract
  • 1 Introduction
  • 2 Epidemiology, genetics and age at onset of dystonias
  • 3 Age-related modifiers of genetic dystonias
  • 4 Converging biochemical and physiologic abnormalities
  • 5 Critical periods of vulnerability for the sensorimotor system: Does it apply to dystonia.
  • 6 A possible common framework: The double-hit hypothesis
  • Disclosures
  • References
  • Chapter Eleven: Dystonia and Parkinson's disease: Do they have a shared biology
  • Abstract
  • 1 Introduction
  • 2 Pathophysiological considerations-Convergence and divergence
  • 3 Dystonia and Parkinson's disease
  • 4 Dystonia and parkinsonism-Beyond PD
  • 5 Conclusion and future directions-One pathway or many
  • References
  • Chapter Twelve: Dystonia and tremor: Do they have a shared biology
  • Abstract
  • 1 Introduction
  • 2 Evidence in favor of shared biology
  • 3 Evidence against a shared biology
  • Conclusion and future perspectives
  • References
  • Chapter Thirteen: How does botulinum toxin really work
  • Abstract
  • 1 Background
  • 2 What is the evidence for a central effect
  • 3 Neurophysiological evidence of BoNT effects on brainstem excitability in humans
  • 4 Neurophysiological evidence of BoNT effects on the sensory system in humans
  • 5 Neuroimaging evidence of central effects of BoNT in humans
  • 6 Conclusions
  • References
  • Chapter Fourteen: What have we learned about the biology of dystonia from deep brain stimulation
  • Abstract
  • References.

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