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|a 1391779440
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|a 9780323990271
|q (electronic bk.)
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|a RC935.D8
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|a 616.83
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|a DYSTONIA
|h [electronic resource].
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|a [S.l.] :
|b ELSEVIER ACADEMIC PRESS,
|c 2023.
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|a 1 online resource.
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|a text
|b txt
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|a International review of neurobiology ;
|v 169
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|a Intro -- Title page -- Table of Contents -- International Review Of Neurobiology: Dystonia -- International Review Of Neurobiology -- Copyright -- Contributors -- Chapter One: Clinical features of dystonia and the science of classification -- Abstract -- 1 Early observations -- 2 Phenomenology -- 3 Motor features -- 4 Diagnosis -- 5 Classification -- 6 Current status and beyond -- References -- Chapter Two: What can epidemiological studies teach on the pathophysiology of adult-onset isolated dystonia -- Abstract -- 1 Introduction -- 2 Studies of birth sex in AOID: Suggestions for pathophysiology -- 3 How does age affect phenotype and natural history of AOID -- 4 Extra-genetic risk factors and mechanisms of AOID -- 5 Clinical and epidemiological studies of non-motor symptoms in AOID: Implications for pathophysiology -- 6 Brain-wide mechanisms and network dysfunction: Supporting evidence from epidemiologic data -- 7 Form-specific mechanisms: Supporting evidence from epidemiologic data -- 8 Where to go next investigating risk- and course-modifying factors of dystonia Conclusive remarks -- References -- Chapter Three: Dystonia genes and their biological pathways -- Abstract -- 1 Introduction -- 2 Concluding remarks and future perspectives -- References -- Chapter Four: The functional anatomy of dystonia: Recent developments -- Abstract -- 1 Introduction -- 2 Neuroimaging in idiopathic dystonia -- 3 Lesion studies -- 4 Animal studies in dystonia -- 5 Pathways of dystonia -- 6 Future directions -- 7 Conclusions -- Acknowledgements -- References -- Chapter Five: Physiology of dystonia: Human studies -- Abstract -- 1 Introduction -- 2 Inhibition -- 3 Plasticity -- 4 Limitations of inhibition and plasticity hypothesis -- 5 Peripheral contributions and disrupted sensorimotor integration -- 6 Oscillations in dystonia -- 7 Conclusions -- References.
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|a Chapter Six: Physiology of Dystonia: Animal Studies -- Abstract -- 1 Introduction -- 2 Genetic mouse models with mutations in dystonia-associated genes that are affected in human patients -- 3 Spontaneous genetic models with dystonic movements -- 4 Neural circuit manipulations causing dystonia -- 5 Pharmacologically-induced dystonia models -- 6 Other models of induced dystonia -- 7 Conclusions -- References -- Chapter Seven: Advances in targeting neurotransmitter systems in dystonia -- Abstract -- 1 Introduction -- 2 Physiology of the principal brain neurotransmitters -- 3 Neurotransmitter-targeting pharmacological therapies -- 4 New evolving genetic therapies targeting neurotransmitter systems -- 5 Discussion -- Acknowledgements -- References -- Chapter Eight: Experimental pharmacology: Targeting metabolic pathways -- Abstract -- 1 Introduction -- 2 Genetic-metabolic conditions causing dystonia with available disease-specific treatment -- 3 Trace element metabolism disorders and NBIA disorders -- 4 Manganese transport disorders -- 5 Aceruloplasminemia -- 6 PKAN -- 7 Energetic metabolism alterations -- 8 Lysosomal disorders -- 9 Neurotransmitter defects -- 10 Channelopathies and synaptopathies -- 11 Conclusive remarks -- References -- Chapter Nine: Adult-onset focal dystonias: To lump or split -- Abstract -- 1 Introduction -- 2 Lumping -- 3 Splitting -- 4 Resolving the paradox -- 5 Conclusions and future prospects -- References -- Chapter Ten: Early-onset inherited dystonias versus late-onset idiopathic dystonias: Same or different biological mechanisms -- Abstract -- 1 Introduction -- 2 Epidemiology, genetics and age at onset of dystonias -- 3 Age-related modifiers of genetic dystonias -- 4 Converging biochemical and physiologic abnormalities -- 5 Critical periods of vulnerability for the sensorimotor system: Does it apply to dystonia.
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|a 6 A possible common framework: The double-hit hypothesis -- Disclosures -- References -- Chapter Eleven: Dystonia and Parkinson's disease: Do they have a shared biology -- Abstract -- 1 Introduction -- 2 Pathophysiological considerations-Convergence and divergence -- 3 Dystonia and Parkinson's disease -- 4 Dystonia and parkinsonism-Beyond PD -- 5 Conclusion and future directions-One pathway or many -- References -- Chapter Twelve: Dystonia and tremor: Do they have a shared biology -- Abstract -- 1 Introduction -- 2 Evidence in favor of shared biology -- 3 Evidence against a shared biology -- Conclusion and future perspectives -- References -- Chapter Thirteen: How does botulinum toxin really work -- Abstract -- 1 Background -- 2 What is the evidence for a central effect -- 3 Neurophysiological evidence of BoNT effects on brainstem excitability in humans -- 4 Neurophysiological evidence of BoNT effects on the sensory system in humans -- 5 Neuroimaging evidence of central effects of BoNT in humans -- 6 Conclusions -- References -- Chapter Fourteen: What have we learned about the biology of dystonia from deep brain stimulation -- Abstract -- References.
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|a Dystonia.
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| 650 |
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|a Dystonia.
|2 fast
|0 (OCoLC)fst00900370
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|i ebook version :
|z 9780323990271
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|c Original
|z 0323990266
|z 9780323990264
|w (OCoLC)1355395929
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| 856 |
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|u https://sciencedirect.uam.elogim.com/science/bookseries/00747742/169
|z Texto completo
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