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|a 616.8
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|a Alternative methods in neurotoxicology /
|c edited by Joao Batista Rocha [and more].
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|a [S.l.] :
|b Academic Press,
|c 2023.
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|a 1 online resource.
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|a text
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|a online resource
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|a Advances in neurotoxicology ;
|v 9
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|a Intro -- Alternative Methods in Neurotoxicology -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Assessment of mitochondrial function in neurotoxicology using alternative model organisms -- 1. Introduction -- 2. Mitochondria as a target for toxicants -- 3. Mitochondrial dysfunction and neurotoxicity -- 4. Mitochondrial function assessment -- 5. Respirometry protocols using alternative model organisms -- 6. Concluding remarks -- Acknowledgments -- References -- Chapter Two: Planarians as a model to study neurotoxic agents -- 1. Introduction -- 2. The planarian system: The basics -- 3. The planarian brain: Structure, function, and regeneration -- 4. Endpoints to assess neurotoxicity in planarians -- 5. Planarian species used in neurotoxicology -- 6. Fitting in: Planarians complement other invertebrate models (nematodes, developing zebrafish) -- 7. Case study: Organophosphorus agents in planarians -- 7.1. Current gaps in understanding the toxicity of organophosphorus agents -- 7.2. Relevancy of the planarian system: Cholinesterases and metabolism -- 7.3. Linking molecular and behavioral outcomes of OP toxicity in planarians -- 8. Concluding remarks -- Acknowledgments -- Conflict of interest -- References -- Chapter Three: The role of Drosophila melanogaster in neurotoxicology studies: Responses to different harmful substances -- 1. Introduction -- 1.1. The neuronal system of Drosophila melanogaster: Development from the embryo to the adult fly -- 2. Drosophila melanogaster as a research model in neurotoxicity -- 2.1. The radiation-induced neurotoxicity in Drosophila melanogaster at different life stages: A model of genomics toxicity -- 2.2. The lead (Pb)-induced neurotoxicity in Drosophila melanogaster at different life stages: A model of heavy metals tox.
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8 |
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|a 2.3. The rotenone-induced neurotoxicity in Drosophila melanogaster at different life stages: A model of pesticide toxicity -- 2.4. The bisphenol A- and microplastics-induced neurotoxicity in Drosophila melanogaster at different life stages: A mode ... -- 3. Concluding remarks -- Acknowledgments -- References -- Chapter Four: Neurotoxicology of metals and metallic nanoparticles in Caenorhabditis elegans -- 1. Introduction -- 2. C. elegans neuronal system -- 3. Metals neurotoxicology in C. elegans -- 3.1. Manganese -- 3.2. Iron -- 3.3. Copper neurotoxicity -- 3.4. Lead neurotoxicity -- 3.5. Mercury neurotoxicity -- 3.6. Cadmium -- 3.7. Aluminum -- 3.8. Metal mixtures -- 3.9. Other metals -- 4. Metallic nanoparticles neurotoxicology in C. elegans -- 4.1. Ag-NPs -- 4.2. Fe-NPs -- 4.3. Al-NPs -- 4.4. Cu-NPs -- 4.5. Au-NPs -- 4.6. Ti-NPs -- 4.7. Cd-NPs -- 4.8. Si-NPs -- 4.9. Other metallic nanoparticles -- 5. Perspectives and concluding remarks -- References -- Chapter Five: Neurotoxicology of organic environmental toxicants using Caenorhabditis elegans as a model -- 1. Introduction -- 2. Caenorhabditis elegans in environmental neurotoxicology -- 3. Environmental neurotoxicants and C. elegans -- 3.1. Pesticides -- 3.1.1. Dithiocarbamates -- 3.1.2. Paraquat -- 3.2. Methylated metals -- 3.3. Micro and nanoplastics -- 3.4. Volatile organic chemicals -- 3.5. Other contaminants -- 3.5.1. Drugs -- 3.5.2. Bisphenol A -- 3.6. Phthalates -- 4. Conclusions and perspectives -- References -- Chapter Six: Nauphoeta cinerea as an emerging model in neurotoxicology -- 1. Introduction -- 2. Lobster cockroach N. cinerea -- 3. Behavioral phenotyping in N. cinerea -- 4. Mechanism based neurotoxicity studies using N. cinerea -- 5. Conclusion -- Acknowledgments -- References.
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|a Chapter Seven: Human neural stem cells in developmental neurotoxicology: Current scenario and future prospects -- 1. Introduction -- 2. Development of the nervous system -- 3. Types of stem cells and their properties/characteristics -- 3.1. Concept of ``stem cell�� -- 3.2. Types of stem cells -- 3.2.1. Totipotent stem cells -- 3.2.2. Pluripotent stem cells -- 3.2.3. Multipotent stem cells -- 3.2.4. Unipotent stem cells -- 4. Bi-dimensional (2D) and tri-dimensional (3D) cell cultures -- 5. Human neural stem cells and neurodevelopmental endpoints -- 5.1. Proposed assays in the DNT IVB using NSC -- 5.2. Other DNT assay based on NSC -- 5.2.1. Neural rosette formation -- 5.2.2. Neuronal subtype differentiation -- 5.2.3. Human synaptogenesis/neural network formation -- 5.2.4. Myelination -- 5.2.5. Other assays with models similar to those included in the DNT IVB -- 6. Present and future expectations -- 6.1. Brain organoids -- 6.2. ``Omics�� and ``in silico�� approaches -- 6.3. Knowledge integration of research data -- References -- Chapter Eight: Perspectives for advancing neurotoxicity studies with Drosophila -- 1. Introduction -- 2. Fly models in current and future advances in neurotoxicology: Overview -- 2.1. Meeting the goals for neurotoxicology studies with flies -- 2.2. Importance of assay choice for neurotoxic endpoints -- 2.3. Developmental assays: Consideration of stage specific neurotoxic endpoints -- 2.3.1. The embryo -- 2.3.2. The larval stage -- 2.3.3. The pupae -- 2.4. Adult assays -- 2.4.1. Conventional toxicity assays -- 2.4.2. Behavior assays -- 2.5. Toxicokinetic endpoints -- 2.5.1. Tissue distribution -- 2.6. Molecular endpoints: In search of pathways and candidate genes in toxicity mechanisms -- 2.6.1. Genomics -- 2.6.2. QTL studies -- 2.6.3. Transcriptomics -- 2.6.4. Single-cell RNA sequencing.
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|a 4. Studies performed on Drosophila PD model for the effect of natural plant products/extract -- 4.1. Flavonoids -- 4.2. Alkaloids -- 4.3. Effect of terpenoids -- 4.4. Effect of plant extracts and infusions -- 5. Conclusions -- References -- Chapter Eleven: Neurotoxicity of iron (Fe) in Drosophila and the protective roles of natural products -- 1. Introduction -- 2. Iron homeostasis in Drosophila -- 2.1. Drosophila orthologues of mammalian iron regulatory proteins -- 2.2. Dietary iron uptake, storage, and efflux in Drosophila -- 3. Iron-induced neurotoxicity in Drosophila -- 4. Protective activity of natural products against iron neurotoxicity in Drosophila -- 4.1. Quercetin -- 4.2. Curcumin -- 4.3. Hesperidin -- 4.4. Epigallocatechin-3-gallate (EGCG) -- 5. Concluding remarks -- References.
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| 650 |
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|a Neurotoxicology.
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| 650 |
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|a Nervous system
|x Diseases
|x Animal models.
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| 650 |
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6 |
|a Neurotoxicologie.
|0 (CaQQLa)201-0041644
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| 650 |
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|a Syst�eme nerveux
|0 (CaQQLa)201-0007359
|x Maladies
|0 (CaQQLa)201-0007359
|x Mod�eles animaux.
|0 (CaQQLa)201-0375873
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|a Nervous system
|x Diseases
|x Animal models
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|0 (OCoLC)fst01036099
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| 650 |
|
7 |
|a Neurotoxicology
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| 700 |
1 |
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|a Rocha, Joao Batista.
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| 776 |
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8 |
|i ebook version :
|z 9780443185830
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| 776 |
0 |
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|c Original
|z 0443185824
|z 9780443185823
|w (OCoLC)1348633282
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|u https://sciencedirect.uam.elogim.com/science/bookseries/24687480/9
|z Texto completo
|
