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|a 363.1799
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|a Ionizing radiation and the immune response.
|n Part A /
|c edited by C�eline Mirjolet, Lorenzo Galluzzi.
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| 260 |
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|a [S.l.] :
|b Academic Press,
|c 2023.
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|a 1 online resource.
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|a text
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|a computer
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|a online resource
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|a International review of cell and molecular biology ;
|v v. 376
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|a Intro -- Ionizing Radiation and the Immune Response -- Part A -- Copyright -- Contents -- Contributors -- Chapter One: Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives -- 1. Introduction -- 2. Charged particles: physics and biology -- 2.1. Physical characteristics of charged particle therapy as opposed to photon therapy -- 2.2. Resulting biological effects and enhanced biological effectiveness for cell death related effects -- 3. Impact of charged particles on the immune response -- 3.1. Biological differences with respect to immunogenicity of the cell death modality -- 3.2. Pre-clinical studies suggesting a match of charged particles with immunotherapy -- 3.3. Impact on immune cells and the tumor immune microenvironment -- 3.4. Sparing of normal tissue leads to reduced lymphopenia -- 3.5. Potential for charged particles in combination with immunotherapy and clinical studies -- 4. Future perspectives -- 5. Conclusions -- Reference -- Chapter Two: Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiothe ... -- 1. Introduction -- 2. FLASH radiation therapy and the immune system -- 2.1. Immune cell sparing in blood and normal tissues -- 2.2. FLASH-RT effects on tumor immune microenvironment -- 2.3. FLASH-RT effects on cytokines production and distant effects -- 2.4. Combination of FLASH-RT with immunotherapy -- 3. Spatially fractionated radiotherapy and radiation-induced immune response -- 3.1. Impact of SFRT on the tumor microenvironment -- 3.2. SFRT effects on inflammation and cytokine secretion -- 3.3. SFRT impact on peripheral immune cells -- 3.4. Abscopal effect and distant effect of healthy tissue irradiation -- 3.5. Long-term antitumor immunity -- 3.6. Combination of SFRT and immunotherapy -- 4. Conclusions -- Acknowledgments.
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|a 3.2.1. T cells -- 3.2.2. Tumor-associated macrophages and myeloid derived suppressor cells -- 3.2.3. Dendritic cells -- 3.2.4. Natural killers -- 4. Radiation therapy and fatty acid metabolism -- 4.1. Fatty acid metabolism promotes radiation therapy resistance -- 4.2. Impact of FA metabolism on RT-induced type I IFN -- 5. Conclusions -- Acknowledgments -- Conflict of interest statement -- References -- Chapter Six: Chemotherapy to potentiate the radiation-induced immune response -- 1. Introduction -- 2. Immunostimulating effects of chemoradiation -- 2.1. Inducing immunogenic cell death -- 2.2. Increase of tumor mutational burden -- 2.3. Promoting dendritic cell maturation and trafficking -- 2.4. Inducing intratumoral T cells infiltration -- 3. Immune suppressive effects of chemoradiation therapy -- 3.1. Regulatory T cells -- 3.2. Macrophages and myeloid-derived-suppressor-cells -- 3.3. Adaptive immune resistance -- 4. Combining CRT with immunotherapy: A promising strategy -- 4.1. Preclinical studies -- 4.2. Synergistic effects of CRT-IO combo in human cancers -- 5. Conclusion -- Acknowledgments -- Author contributions -- References.
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| 650 |
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|a Ionizing radiation
|x Health aspects.
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| 650 |
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|a Immune response.
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| 650 |
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6 |
|a R�eaction immunitaire.
|0 (CaQQLa)201-0013536
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| 650 |
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|a Immune response
|2 fast
|0 (OCoLC)fst00967867
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| 650 |
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7 |
|a Ionizing radiation
|x Health aspects
|2 fast
|0 (OCoLC)fst00978648
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| 700 |
1 |
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|a Mirjolet, C�eline.
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| 700 |
1 |
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|a Galluzzi, Lorenzo.
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| 776 |
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|i ebook version :
|z 9780323955249
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| 776 |
0 |
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|c Original
|z 0323955231
|z 9780323955232
|w (OCoLC)1346350120
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| 856 |
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|u https://sciencedirect.uam.elogim.com/science/bookseries/19376448/376
|z Texto completo
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