WNT signaling in development and disease /

Wnt Signaling in Development and Disease, Volume 153 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapter on topics such as The cell biology of Wnt gradient formation, Approaches to visualize and trace Wnt si...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Yamaguchi, Terry P., Willert, Karl
Formato: eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2023.
Colección:Current topics in developmental biology ; v. 153.
Temas:
Wnt proteins.
Cellular signal transduction.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Wnt Signaling in Development and Disease
  • Copyright
  • Contents
  • Contributors
  • Preface
  • References
  • Chapter One: The logistics of Wnt production and delivery
  • 1. Wnt production and delivery: A complex logistical problem
  • 2. Lipidation
  • 2.1. An unusual lipid modification
  • 2.2. Porcupine: An enzyme dedicated to Wnt lipidation
  • 3. Glycosylation
  • 4. Progression through the secretory pathway
  • 4.1. Wntless escorts Wnts through the secretory pathway
  • 4.2. Binding of Wnts to Wntless
  • 4.3. Other players acting in the ER and Golgi
  • 5. Beyond Wls
  • 5.1. Wnt trafficking in epithelial cells
  • 5.2. Let Wnt go
  • 6. Transport and gradient formation
  • 6.1. Juxtacrine signaling
  • 6.2. Evidence for long range signaling
  • 6.3. Long range signaling by cytonemes
  • 6.4. Long range signaling by diffusion
  • 7. Wnt interactions with HSPGs and glypicans
  • 7.1. HSPGs modulate multiple signaling pathways
  • 7.2. The role of glypicans in Wnt transport
  • 8. Other means of shielding the Wnt lipid in the extracellular space
  • 9. Wnts reach their receptors: Handover and initiation of signaling
  • 10. How a lipidated morphogen came to be during evolution
  • Acknowledgments
  • References
  • Chapter Two: Visualizing WNT signaling in mammalian systems
  • 1. Introduction
  • 2. Imaging individual players at the molecular level
  • 2.1. The signalosome
  • 2.1.1. WNT ligands
  • 2.1.2. Frizzled/LRP and disheveled
  • 2.2. The CTNNB1 destruction complex and enhanceosome
  • 2.2.1. Destruction complex
  • 2.2.2. CTNNB1
  • 2.2.3. TCF/LEF
  • 3. Imaging signaling output at the cellular level
  • 3.1. A brief history of TCF/LEF reporters
  • 3.2. 7x TCF-GFP in cell lines
  • 3.3. WNT reporters in mice
  • 3.3.1. TCF/LEF reporters in mice
  • 3.3.2. Axin2 reporter strains
  • 4. Discussion and outlook
  • Acknowledgments
  • References.
  • 3.3. Developmental transitions through pluripotency stages are regulated by Wnt signaling
  • 4. Role of Wnts in gastrulation
  • 4.1. The primitive streak (PS) and early gastrulation
  • 4.2. Axial progenitors
  • 4.3. The trunk-to-tail transition
  • 4.4. Axial progenitors and retinoic acid
  • 5. Closing remarks
  • References
  • Chapter Six: Role of Wnt signaling and planar cell polarity in left-right asymmetry
  • 1. Canonical Wnt signaling regulates the formation of the node, the left-right organizer
  • 2. Non-canonical Wnt signaling and planar cell polarity determines the tilt of motile cilia at the node
  • 2.1. Motile and immotile cilia are required for establishing L-R asymmetry
  • 2.2. The tilt of motile cilia is determined by the position of the basal body in node cells
  • 2.3. Correct positioning of the basal body by planar cell polarity genes
  • 2.4. Graded distribution of Wnt5a activity along the antero-posterior axis of the mouse embryo polarizes node cells
  • 2.5. Microtubules and actomyosin provide pushing force for shifting the basal body position
  • 3. Canonical Wnt signaling in establishing asymmetric nodal activity at the node
  • 4. Conclusions
  • Acknowledgments
  • References
  • Chapter Seven: Non-canonical WNT5A-ROR signaling: New perspectives on an ancient developmental pathway
  • 1. A brief history of canonical and non-canonical WNT pathways
  • 2. Emergence of WNT5A-ROR signaling as a major non-canonical WNT pathway
  • 3. Robinow syndrome as a disorder of WNT5A-ROR signaling
  • 4. Molecular insights from Robinow syndrome and related disease mutations
  • 4.1. WNT5A
  • 4.2. ROR2
  • 4.3. Dishevelleds
  • 4.4. Frizzled 2
  • 5. Growing connections to cancer metastasis
  • 6. Cell biological functions of WNT5A-ROR signaling
  • 7. Concluding remarks
  • Acknowledgments
  • References.
  • Chapter Eight: The role of Wnt signaling in Xenopus neural induction
  • 1. Introduction
  • 1.1. Neural induction from newt to frog
  • 1.2. The anatomy of the Xenopus gastrula/neurula embryo
  • 2. The arising of embryonic signaling centers
  • 2.1. The Nieuwkoop center and the formation of the Spemann organizer
  • 3. The Wnt pathway discovery and its impact on X. laevis embryogenesis
  • 3.1. How cancer biology and the Wnt pathway discovery impacted the understanding of Xenopus embryogenesis
  • 3.2. Revealing molecular induction properties: Is there room for one more organizer?
  • 4. The BMP signaling pathway and the neural default model
  • 5. WNT morphogen activity and its impact on Xenopus AP embryonic neural patterning
  • 5.1. Wnt inhibitors are involved in neural induction and head formation
  • 5.2. Wnt antagonists secreted from Spemann organizer
  • 5.3. Wnt antagonists secreted in N�ave ectoderm
  • 6. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Nine: Wnt regulation of hematopoietic stem cell development and disease
  • 1. Hematopoietic stem cells-The source of our blood and immune cell pool
  • 2. In vivo models for hematopoietic stem cell development
  • 3. Wnt signaling
  • 4. Wnt signaling in HSC development and homeostasis
  • 5. Wnt signaling and hematological malignancies
  • 6. Epigenetic regulation in HSCs and Wnt signaling
  • 7. Conclusion
  • References
  • Chapter Ten: Role of Wnt signaling in the maintenance and regeneration of the intestinal epithelium
  • 1. Introduction
  • 2. Overview of the Wnt pathway
  • 3. Organization of the intestinal epithelium
  • 3.1. The organoid model
  • 4. Wnt pathway in intestinal homeostasis and regeneration
  • 4.1. Modulation of Wnt signaling during homeostasis
  • 4.2. Determination of the stem cell state
  • 4.3. Reconstituting the stem cell pool after injury.
  • 5. Regulation of Wnt signaling by the intestinal niche
  • 5.1. Paneth cells
  • 5.2. Deep crypt secretory cells
  • 5.3. Stromal cells
  • 5.4. Immune and lymphatic cells
  • 5.5. Nervous system
  • 5.6. Extracellular matrix
  • 5.7. Flora
  • 5.8. Nutrition
  • 6. Discussion
  • References
  • Chapter Eleven: Got WNTS? Insight into bone health from a WNT perspective
  • 1. Bone development
  • 2. Wnt signaling in limb development
  • 3. Wnt signaling and human skeletal malformations
  • 4. Wnt signaling and bone homeostasis
  • 5. Therapeutics and future directions
  • Acknowledgments
  • References
  • Chapter Twelve: Wnt signaling in whole-body regeneration
  • 1. Introduction
  • 2. Planarian regeneration is supported by pluripotent adult stem cells
  • 3. Planarians have constitutive Wnt positional information specified from muscle
  • 4. Injury-induced Wnt signals regulate the polarity of blastema outgrowth
  • 5. Constitutive Wnt gradients pattern the AP axis in homeostasis and regeneration
  • 6. Wnts control reestablishment of tissue proportionality in planarian regeneration
  • 7. Wnt signaling from muscle controls AP regeneration of the Acoel Hofstenia miamia
  • 8. Wnt signaling controls oral-aboral identity in whole-body regeneration of Cnidarians
  • 9. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Thirteen: From injury to patterning-MAPKs and Wnt signaling in Hydra
  • 1. Introduction
  • 2. Wnt signaling in Hydra axis formation
  • 3. Autocatalytic Wnt activation and Wnt inhibitors in Hydra pattern formation
  • 4. Cell cycle dynamics of Hydra regeneration
  • 5. Transcriptomic and (phospho-) proteomic profiles of Hydra regeneration
  • 6. A dual role of Wnt signaling in regeneration
  • 7. The injury signal in Hydra
  • 7.1. ROS and calcium
  • 7.2. Mitogen activated protein kinases ERK, JNK, and p38
  • 7.3. Cell competition and apoptosis.

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