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| LEADER |
00000cam a22000007a 4500 |
| 001 |
SCIDIR_on1369699989 |
| 003 |
OCoLC |
| 005 |
20231120010726.0 |
| 006 |
m o d |
| 007 |
cr un|---aucuu |
| 008 |
230215t20232023maua ob 000 0 eng d |
| 040 |
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|a YDX
|b eng
|c YDX
|d OPELS
|d SFB
|d AAA
|d OCLCF
|d OCLCO
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| 019 |
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|a 1370201483
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| 020 |
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|a 9780323992015
|q (electronic bk.)
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| 020 |
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|a 0323992013
|q (electronic bk.)
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| 020 |
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|z 9780323992008
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| 020 |
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|z 0323992005
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| 035 |
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|a (OCoLC)1369699989
|z (OCoLC)1370201483
|
| 050 |
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4 |
|a QP609.P78
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| 082 |
0 |
4 |
|a 572.76
|2 23/eng/20230215
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| 245 |
0 |
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|a Targeted protein degradation /
|c edited by George L. Burslem.
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| 264 |
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1 |
|a Cambridge :
|b Academic Press,
|c 2023.
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| 264 |
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4 |
|c �2023
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| 300 |
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|a 1 online resource (xvi, 323 pages) :
|b illustrations (chiefly color)
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Methods in enzymology ;
|v v. 681
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| 505 |
0 |
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|a One - High-efficiency knock-in of degradable tags (dTAG) at endogenous loci in cell lines -- Two - High throughput E3 ligase degron binding assays for novel PROTAC ligand discovery -- Three - Synthesis of SNIPERs against BCR-ABL with kinase inhibitors and a method to evaluate their growth inhibitory activity derived from BCR-ABL degradation -- Four - Harnessing nanobodies for target protein degradation through the Affinity-directed PROtein Missile (AdPROM) system -- Five - Monitoring PROTAC interactions in biochemical assays using Lumit immunoassays -- Six - The In-Cell Western immunofluorescence assay to monitor PROTAC mediated protein degradation -- Seven - Cereblon target validation using a covalent inhibitor of neosubstrate recruitment -- Eight - Advancing targeted protein degrader discovery by measuring cereblon engagement in cells -- Nine - Quantitative measurement of PROTAC intracellular accumulation -- Ten - The importance of controls in targeted protein degradation: Determining mechanism -- Eleven - Crystallization of VHL-based PROTAC-induced ternary complexes -- Twelve - Targeted protein degradation through light-activated E3 ligase recruitment -- Thirteen - A heterobifunctional molecule system for targeted protein acetylation in cells
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| 504 |
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|a Includes bibliographical references.
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| 650 |
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0 |
|a Proteolytic enzymes.
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| 650 |
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|a Proteolysis.
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| 650 |
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6 |
|a Enzymes prot�eolytiques.
|0 (CaQQLa)201-0055592
|
| 650 |
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6 |
|a Prot�eolyse.
|0 (CaQQLa)000293714
|
| 650 |
|
7 |
|a Proteolysis
|2 fast
|0 (OCoLC)fst01930489
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| 650 |
|
7 |
|a Proteolytic enzymes
|2 fast
|0 (OCoLC)fst01079783
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| 700 |
1 |
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|a Burslem, George L.,
|e editor.
|
| 776 |
0 |
8 |
|c Original
|z 0323992005
|z 9780323992008
|w (OCoLC)1330407346
|
| 830 |
|
0 |
|a Methods in enzymology ;
|v v. 681.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/00766879/681
|z Texto completo
|
