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Advances in heterocyclic chemistry. Volume 140 /

Detalles Bibliográficos
Clasificación:	Libro Electrónico
Otros Autores:	Scriven, Eric F. V., Ramsden, Christopher A., 1946-
Formato:	eBook
Idioma:	Inglés
Publicado:	[S.l.] : Academic Press, 2023.
Temas:	Heterocyclic chemistry.
Acceso en línea:	Texto completo

Tabla de Contenidos:

Intro
Advances in Heterocyclic Chemistry
Copyright
Contents
Contributors
Preface
Chapter One: The application of the Fischer indole synthesis in medicinal chemistry
1. Introduction
2. Mechanism of the Fischer indole synthesis
2.1. Catalysis of the Fischer indole synthesis
2.2. Regioselectivity of the Fischer indole synthesis
2.2.1. Theoretical studies
2.3. Enantioselective Fischer indole synthesis
3. The scope of the Fischer indole synthesis
3.1. Aryl hydrazines and hydrazones
3.2. The Japp-Klingemann reaction
4. Applications in medicinal chemistry
4.1. Cancer
4.2. Diabetes
4.3. Medical imaging
4.4. Osteoporosis
4.5. Tuberculosis
4.6. Alzheimer�s disease
4.7. Antifungal, antiprotozoal, antimicrobial
4.8. Depression
4.9. Migraine
4.10. Pesticides (herbicides and fungicides)
4.11. Inflammation
4.12. Flow chemistry
References
Chapter Two: Oxindole synthesis via CH activation methods
1. Introduction
Oxindole synthesis via C-H activation methods
2.1. Oxindole synthesis using carbamoyl chlorides
2.2. Oxindole synthesis using anilides
2.3. Oxindole synthesis using acrylamides
2.4. Oxindole synthesis using propiolamides
3. Concluding remarks
Acknowledgments
References
Chapter Three: Ring-closing metathesis in the synthesis of fused indole structures
1. Introduction
2. Synthesis of Fused Indoles via RCM
2.1. Formation of five-membered cycles
2.2. Formation of six-membered cycles
2.3. Formation of seven-membered and bigger cycles
3. Concluding remarks
Acknowledgments
References
Chapter Four: Bis-aldehydes: Versatile precursors for bis-heterocycles
1. Introduction
2. Synthesis of bis-aldehydes
2.1. Bis-aldehydes linked to aliphatic spacers via ether linkages.
2.2. Bis-aldehydes linked to aromatic or heteroaromatic spacers via ether linkages
2.3. Bis-pyrazole-aldehydes linked to aliphatic or aromatic spacers via ether linkages
2.4. Bis-aldehydes linked to aliphatic or aromatic spacers via ester linkages
2.5. Bis-aldehydes linked to aliphatic or aromatic spacers via ether-amide linkages
2.6. Bis-aldehydes linked to aliphatic spacers via ester-amide linkages
2.7. Bis-aldehydes linked to piperazine linker
2.8. Bis-indole-3-carboxaldehydes linked to aliphatic spacers
3. Synthesis of bis-heterocycles
3.1. Five-membered heterocycles
3.1.1. Bis-furan
3.1.2. Bis-imidazole
3.1.3. Bis-thiazole
3.1.4. Bis-oxazole
3.1.5. Bis-triazole
3.2. Six-membered heterocycles
3.2.1. Bis(pyridine)
3.2.2. Bis-pyrimidine
3.2.3. Bis(di(uracil))
3.2.4. Bis-1,2,4-triazine
3.3. Synthesis of fused bicyclic system
3.3.1. Fused [5-6] systems: Two heteroatoms
3.3.1.1. Bis(di(1H-indole)
3.3.1.2. Bis(benzimidazoles) and bis(benzothiazoles)
3.3.1.3. Bis(pyrazolo[1,5-a]pyridine)
3.3.2. Fused [5-6] systems: Three heteroatoms
3.3.2.1. Imidazo[4,5-b]pyridine
3.3.2.2. Pyrano[2,3-c]pyrazole
3.3.3. Fused [6-6] systems: One heteroatom
3.3.3.1. Bis(2H-chromene)
3.3.3.2. Bis(di-2H-chromen-2-one)
3.3.3.3. Bis-4H-chromeneone
3.3.3.4. Bis-tetrahydroquinolines
3.3.4. Fused [6-6] systems: Three heteroatoms
3.3.4.1. Bis-(pyrimido[5,4-d]pyrimidine)
3.4. Synthesis of fused tricyclic system
3.4.1. Fused [5-5-6] systems: Five heteroatoms
3.4.1.1. Bis(dipyrazolo-pyridine)
3.4.2. Fused [5-6-6] systems: Three heteroatoms
3.4.2.1. [1,2,4]Triazolo[3,4-a]isoquinoline
3.4.3. Fused [5-6-6] systems: Four heteroatoms
3.4.3.1. 1,4-Dihydropyrazolo[4,3:5,6]pyrano[2,3-b]pyridines
3.4.3.2. [1,2,4]Triazolo[5,1-b]quinazolines.
3.4.4. Fused [6-5-6] systems: Four heteroatoms
3.4.4.1. Pyrido[2,3:3,4]pyrazolo[1,5-a]pyrimidines
3.4.5. Fused [6-6-6] systems: One heteroatoms
3.4.5.1. Bis(hexahydro-1H-xanthene)
3.4.5.2. Bis(5H-acridines)
3.4.5.3. Bis(pyrido-isoquinoline)
3.4.6. Fused [6-6-6] systems: Two heteroatoms
3.4.6.1. Bis(3H-chromeno[3,4-c]pyridine)
3.4.6.2. Pyrano[3,2-c]chromenes
3.4.6.3. Bis(chromeno[2,3-b]pyridine)
3.4.7. Fused [6-6-6] systems: Three heteroatoms
3.4.7.1. Bis(pyrimido-quinoline)
3.4.8. Fused [6-6-6] systems: Five heteroatoms
3.4.8.1. Pyrido[2,3-d:6,5-d�]dipyrimidine
3.5. Synthesis of fused tetracyclic system
3.5.1. Fused [6-6-6-5] systems: One heteroatoms
3.5.1.1. 1H-Phenanthro[9,10-d]imidazole
3.5.2. Fused [6-5-6-6] systems: Three heteroatoms
3.5.2.1. Bis(indino-pyrido-pyrimidine)
3.5.2.2. Benzo[4,5]imidazo[2,1-b]quinazoline
3.5.3. Fused [6-6-6-6] systems: One heteroatom
3.5.3.1. Bis(dihydro-8H-benzo[a]xanthene
3.6. Synthesis of fused pentacyclic system
3.6.1. Fused [6-6-6-6-6] systems: One heteroatom
3.6.1.1. Dibenzo[a,j]xanthen
3.6.2. Fused [6-6-6-6-6] systems: Two heteroatoms
3.6.2.1. Bis(pyrano[3,2-c:5,6-c]dichromene
4. Conclusions
References
Chapter Five: The literature of heterocyclic chemistry, Part XX, 2020
1. Introduction
2. General sources and topics
2.1. General books and reviews
2.1.1. Textbooks and handbooks
2.1.2. Annual reports
2.1.3. Specialized reports devoted to one or several recent years
2.1.4. History of heterocyclic chemistry, biographies
2.1.5. Bibliography of monographs and reviews
2.2. General topics by reaction type
2.2.1. General sources and topics
2.2.2. Structure and stereochemistry
2.2.2.1. Stereochemical aspects.
2.2.2.2. Betaines and other unusual structures, in particular, N-heterocycli carbenes (NHC)
2.2.3. Reactivity
2.2.3.1. General topics
2.2.3.2. Reactions with electrophiles and oxidants
2.2.3.3. Reactions with nucleophiles and reducing agents
2.2.3.4. Reactions toward free radicals, carbenes, etc
2.2.3.5. Cross-coupling and related reactions
2.2.3.6. Heterocycles as intermediates in organic synthesis
2.2.3.7. Organocatalysts
2.2.4. Synthesis
2.2.4.1. General topics and nonconventional synthetic methodologies
2.2.4.2. Synthetic strategies and individual methods
2.2.4.2.1. General problems
2.2.4.2.2. Synthetic application of photo reactions and alternative energy input
2.2.4.2.3. Synthetic application of metal-catalyzed reactions
2.2.4.2.4. Synthesis of heterocycles via cycloaddition and multicomponent reactions
2.2.4.2.5. Miscellaneous methods
2.2.4.3. Versatile synthons and specific reagents
2.2.4.4. Ring synthesis from nonheterocyclic compounds
2.2.5. Properties and applications (except drugs and pesticides)
2.2.5.1. Dyes and intermediates
2.2.5.2. Substances with luminescent and related properties
2.2.5.3. Organic conductors and photovoltaics
2.2.5.4. Coordination compounds
2.2.5.5. Polymers
2.2.5.6. Ionic liquids
2.2.5.7. Miscellaneous
2.3. Specialized heterocycles
2.3.1. Nitrogen heterocycles (except alkaloids)
2.3.2. Oxygen heterocycles
2.3.3. Sulfur and selenium heterocycles
2.4. Natural and synthetic biologically active heterocycles
2.4.1. General sources and topics
2.4.1.1. Biological functions of natural and synthetic bioactive heterocycles
2.4.1.2. General approaches to syntheses of biologically active heterocycles
2.4.1.3. Total syntheses of natural products
2.4.2. Alkaloids
2.4.2.1. General
2.4.2.2. Synthesis.
2.4.2.3. Individual groups of alkaloids
2.4.3. Drugs
2.4.3.1. General
2.4.3.1.1. Antibacterial activity
2.4.3.1.2. Antitumor activity
2.4.3.1.3. CNS targeted drugs
2.4.3.1.4. Anti-HIV activity
2.4.3.1.5. Antimalarial and related activity
2.4.3.1.6. Antitubercular activity
2.4.3.1.7. Cardiovascular activity
2.4.3.1.8. Receptor antagonisting and relative activities
2.4.3.2. Individual substances and groups of compounds
2.4.4. Miscellaneous
2.4.4.1. Enzymes, coenzymes, and their models
2.4.4.2. Amino acids and peptides
2.4.4.3. Plant metabolites
2.4.4.4. Heterocycles produced by marine organisms
2.4.4.5. Other natural products
3. Three-membered rings
3.1. One heteroatom
3.1.1. One nitrogen atom
3.1.2. One oxygen atom
4. Four-membered rings
4.1. One nitrogen atom
4.2. One oxygen or Sulfur atom
5. Five-membered rings
5.1. One heteroatom
5.1.1. One nitrogen atom
5.1.1.1. Monocyclic pyrroles and hydropyrroles
5.1.1.2. Porphyrins and related systems
5.1.1.3. Indoles, carbazoles, related systems, and hydrogenated derivatives
5.1.1.4. Isoindoles (including phthalocyanins and porphyrazines)
5.1.1.5. Pyrroles annulated with heterocycles
5.1.2. One oxygen atom
5.1.2.1. Furans
5.1.2.2. Annulated furans
5.1.3. One Sulfur Atom
5.2. Two heteroatoms
5.2.1. Two nitrogen atoms
5.2.1.1. Pyrazoles and annulated pyrazoles
5.2.1.2. Imidazoles and annulated imidazoles
5.2.2. One nitrogen and one oxygen atom
5.2.2.1. 1,2-Heterocycles
5.2.2.2. 1,3-Heterocycles
5.2.3. One nitrogen and one sulfur atom
5.2.4. Two oxygen atoms
5.3. Three heteroatoms
5.3.1. Three nitrogen atoms
5.3.2. Two nitrogen atoms and one oxygen or sulfur atom
5.4. Four heteroatoms
6. Six-membered rings
6.1. One heteroatom
6.1.1. One nitrogen atom.

Advances in heterocyclic chemistry. Volume 140 /

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