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|a 1369602041
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|a 9780443193156
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|a (OCoLC)1369600317
|z (OCoLC)1369602041
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|a 547.59
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|a Advances in heterocyclic chemistry.
|n Volume 140 /
|c edited by Eric F.V. Scriven, Christopher A. Ramsden.
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| 260 |
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|a [S.l.] :
|b Academic Press,
|c 2023.
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|a 1 online resource
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|a Intro -- Advances in Heterocyclic Chemistry -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: The application of the Fischer indole synthesis in medicinal chemistry -- 1. Introduction -- 2. Mechanism of the Fischer indole synthesis -- 2.1. Catalysis of the Fischer indole synthesis -- 2.2. Regioselectivity of the Fischer indole synthesis -- 2.2.1. Theoretical studies -- 2.3. Enantioselective Fischer indole synthesis -- 3. The scope of the Fischer indole synthesis -- 3.1. Aryl hydrazines and hydrazones -- 3.2. The Japp-Klingemann reaction -- 4. Applications in medicinal chemistry -- 4.1. Cancer -- 4.2. Diabetes -- 4.3. Medical imaging -- 4.4. Osteoporosis -- 4.5. Tuberculosis -- 4.6. Alzheimer�s disease -- 4.7. Antifungal, antiprotozoal, antimicrobial -- 4.8. Depression -- 4.9. Migraine -- 4.10. Pesticides (herbicides and fungicides) -- 4.11. Inflammation -- 4.12. Flow chemistry -- References -- Chapter Two: Oxindole synthesis via CH activation methods -- 1. Introduction -- Oxindole synthesis via C-H activation methods -- 2.1. Oxindole synthesis using carbamoyl chlorides -- 2.2. Oxindole synthesis using anilides -- 2.3. Oxindole synthesis using acrylamides -- 2.4. Oxindole synthesis using propiolamides -- 3. Concluding remarks -- Acknowledgments -- References -- Chapter Three: Ring-closing metathesis in the synthesis of fused indole structures -- 1. Introduction -- 2. Synthesis of Fused Indoles via RCM -- 2.1. Formation of five-membered cycles -- 2.2. Formation of six-membered cycles -- 2.3. Formation of seven-membered and bigger cycles -- 3. Concluding remarks -- Acknowledgments -- References -- Chapter Four: Bis-aldehydes: Versatile precursors for bis-heterocycles -- 1. Introduction -- 2. Synthesis of bis-aldehydes -- 2.1. Bis-aldehydes linked to aliphatic spacers via ether linkages.
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|a 2.2. Bis-aldehydes linked to aromatic or heteroaromatic spacers via ether linkages -- 2.3. Bis-pyrazole-aldehydes linked to aliphatic or aromatic spacers via ether linkages -- 2.4. Bis-aldehydes linked to aliphatic or aromatic spacers via ester linkages -- 2.5. Bis-aldehydes linked to aliphatic or aromatic spacers via ether-amide linkages -- 2.6. Bis-aldehydes linked to aliphatic spacers via ester-amide linkages -- 2.7. Bis-aldehydes linked to piperazine linker -- 2.8. Bis-indole-3-carboxaldehydes linked to aliphatic spacers -- 3. Synthesis of bis-heterocycles -- 3.1. Five-membered heterocycles -- 3.1.1. Bis-furan -- 3.1.2. Bis-imidazole -- 3.1.3. Bis-thiazole -- 3.1.4. Bis-oxazole -- 3.1.5. Bis-triazole -- 3.2. Six-membered heterocycles -- 3.2.1. Bis(pyridine) -- 3.2.2. Bis-pyrimidine -- 3.2.3. Bis(di(uracil)) -- 3.2.4. Bis-1,2,4-triazine -- 3.3. Synthesis of fused bicyclic system -- 3.3.1. Fused [5-6] systems: Two heteroatoms -- 3.3.1.1. Bis(di(1H-indole) -- 3.3.1.2. Bis(benzimidazoles) and bis(benzothiazoles) -- 3.3.1.3. Bis(pyrazolo[1,5-a]pyridine) -- 3.3.2. Fused [5-6] systems: Three heteroatoms -- 3.3.2.1. Imidazo[4,5-b]pyridine -- 3.3.2.2. Pyrano[2,3-c]pyrazole -- 3.3.3. Fused [6-6] systems: One heteroatom -- 3.3.3.1. Bis(2H-chromene) -- 3.3.3.2. Bis(di-2H-chromen-2-one) -- 3.3.3.3. Bis-4H-chromeneone -- 3.3.3.4. Bis-tetrahydroquinolines -- 3.3.4. Fused [6-6] systems: Three heteroatoms -- 3.3.4.1. Bis-(pyrimido[5,4-d]pyrimidine) -- 3.4. Synthesis of fused tricyclic system -- 3.4.1. Fused [5-5-6] systems: Five heteroatoms -- 3.4.1.1. Bis(dipyrazolo-pyridine) -- 3.4.2. Fused [5-6-6] systems: Three heteroatoms -- 3.4.2.1. [1,2,4]Triazolo[3,4-a]isoquinoline -- 3.4.3. Fused [5-6-6] systems: Four heteroatoms -- 3.4.3.1. 1,4-Dihydropyrazolo[4,3:5,6]pyrano[2,3-b]pyridines -- 3.4.3.2. [1,2,4]Triazolo[5,1-b]quinazolines.
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|a 3.4.4. Fused [6-5-6] systems: Four heteroatoms -- 3.4.4.1. Pyrido[2,3:3,4]pyrazolo[1,5-a]pyrimidines -- 3.4.5. Fused [6-6-6] systems: One heteroatoms -- 3.4.5.1. Bis(hexahydro-1H-xanthene) -- 3.4.5.2. Bis(5H-acridines) -- 3.4.5.3. Bis(pyrido-isoquinoline) -- 3.4.6. Fused [6-6-6] systems: Two heteroatoms -- 3.4.6.1. Bis(3H-chromeno[3,4-c]pyridine) -- 3.4.6.2. Pyrano[3,2-c]chromenes -- 3.4.6.3. Bis(chromeno[2,3-b]pyridine) -- 3.4.7. Fused [6-6-6] systems: Three heteroatoms -- 3.4.7.1. Bis(pyrimido-quinoline) -- 3.4.8. Fused [6-6-6] systems: Five heteroatoms -- 3.4.8.1. Pyrido[2,3-d:6,5-d�]dipyrimidine -- 3.5. Synthesis of fused tetracyclic system -- 3.5.1. Fused [6-6-6-5] systems: One heteroatoms -- 3.5.1.1. 1H-Phenanthro[9,10-d]imidazole -- 3.5.2. Fused [6-5-6-6] systems: Three heteroatoms -- 3.5.2.1. Bis(indino-pyrido-pyrimidine) -- 3.5.2.2. Benzo[4,5]imidazo[2,1-b]quinazoline -- 3.5.3. Fused [6-6-6-6] systems: One heteroatom -- 3.5.3.1. Bis(dihydro-8H-benzo[a]xanthene -- 3.6. Synthesis of fused pentacyclic system -- 3.6.1. Fused [6-6-6-6-6] systems: One heteroatom -- 3.6.1.1. Dibenzo[a,j]xanthen -- 3.6.2. Fused [6-6-6-6-6] systems: Two heteroatoms -- 3.6.2.1. Bis(pyrano[3,2-c:5,6-c]dichromene -- 4. Conclusions -- References -- Chapter Five: The literature of heterocyclic chemistry, Part XX, 2020 -- 1. Introduction -- 2. General sources and topics -- 2.1. General books and reviews -- 2.1.1. Textbooks and handbooks -- 2.1.2. Annual reports -- 2.1.3. Specialized reports devoted to one or several recent years -- 2.1.4. History of heterocyclic chemistry, biographies -- 2.1.5. Bibliography of monographs and reviews -- 2.2. General topics by reaction type -- 2.2.1. General sources and topics -- 2.2.2. Structure and stereochemistry -- 2.2.2.1. Stereochemical aspects.
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|a 2.2.2.2. Betaines and other unusual structures, in particular, N-heterocycli carbenes (NHC) -- 2.2.3. Reactivity -- 2.2.3.1. General topics -- 2.2.3.2. Reactions with electrophiles and oxidants -- 2.2.3.3. Reactions with nucleophiles and reducing agents -- 2.2.3.4. Reactions toward free radicals, carbenes, etc -- 2.2.3.5. Cross-coupling and related reactions -- 2.2.3.6. Heterocycles as intermediates in organic synthesis -- 2.2.3.7. Organocatalysts -- 2.2.4. Synthesis -- 2.2.4.1. General topics and nonconventional synthetic methodologies -- 2.2.4.2. Synthetic strategies and individual methods -- 2.2.4.2.1. General problems -- 2.2.4.2.2. Synthetic application of photo reactions and alternative energy input -- 2.2.4.2.3. Synthetic application of metal-catalyzed reactions -- 2.2.4.2.4. Synthesis of heterocycles via cycloaddition and multicomponent reactions -- 2.2.4.2.5. Miscellaneous methods -- 2.2.4.3. Versatile synthons and specific reagents -- 2.2.4.4. Ring synthesis from nonheterocyclic compounds -- 2.2.5. Properties and applications (except drugs and pesticides) -- 2.2.5.1. Dyes and intermediates -- 2.2.5.2. Substances with luminescent and related properties -- 2.2.5.3. Organic conductors and photovoltaics -- 2.2.5.4. Coordination compounds -- 2.2.5.5. Polymers -- 2.2.5.6. Ionic liquids -- 2.2.5.7. Miscellaneous -- 2.3. Specialized heterocycles -- 2.3.1. Nitrogen heterocycles (except alkaloids) -- 2.3.2. Oxygen heterocycles -- 2.3.3. Sulfur and selenium heterocycles -- 2.4. Natural and synthetic biologically active heterocycles -- 2.4.1. General sources and topics -- 2.4.1.1. Biological functions of natural and synthetic bioactive heterocycles -- 2.4.1.2. General approaches to syntheses of biologically active heterocycles -- 2.4.1.3. Total syntheses of natural products -- 2.4.2. Alkaloids -- 2.4.2.1. General -- 2.4.2.2. Synthesis.
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|a 2.4.2.3. Individual groups of alkaloids -- 2.4.3. Drugs -- 2.4.3.1. General -- 2.4.3.1.1. Antibacterial activity -- 2.4.3.1.2. Antitumor activity -- 2.4.3.1.3. CNS targeted drugs -- 2.4.3.1.4. Anti-HIV activity -- 2.4.3.1.5. Antimalarial and related activity -- 2.4.3.1.6. Antitubercular activity -- 2.4.3.1.7. Cardiovascular activity -- 2.4.3.1.8. Receptor antagonisting and relative activities -- 2.4.3.2. Individual substances and groups of compounds -- 2.4.4. Miscellaneous -- 2.4.4.1. Enzymes, coenzymes, and their models -- 2.4.4.2. Amino acids and peptides -- 2.4.4.3. Plant metabolites -- 2.4.4.4. Heterocycles produced by marine organisms -- 2.4.4.5. Other natural products -- 3. Three-membered rings -- 3.1. One heteroatom -- 3.1.1. One nitrogen atom -- 3.1.2. One oxygen atom -- 4. Four-membered rings -- 4.1. One nitrogen atom -- 4.2. One oxygen or Sulfur atom -- 5. Five-membered rings -- 5.1. One heteroatom -- 5.1.1. One nitrogen atom -- 5.1.1.1. Monocyclic pyrroles and hydropyrroles -- 5.1.1.2. Porphyrins and related systems -- 5.1.1.3. Indoles, carbazoles, related systems, and hydrogenated derivatives -- 5.1.1.4. Isoindoles (including phthalocyanins and porphyrazines) -- 5.1.1.5. Pyrroles annulated with heterocycles -- 5.1.2. One oxygen atom -- 5.1.2.1. Furans -- 5.1.2.2. Annulated furans -- 5.1.3. One Sulfur Atom -- 5.2. Two heteroatoms -- 5.2.1. Two nitrogen atoms -- 5.2.1.1. Pyrazoles and annulated pyrazoles -- 5.2.1.2. Imidazoles and annulated imidazoles -- 5.2.2. One nitrogen and one oxygen atom -- 5.2.2.1. 1,2-Heterocycles -- 5.2.2.2. 1,3-Heterocycles -- 5.2.3. One nitrogen and one sulfur atom -- 5.2.4. Two oxygen atoms -- 5.3. Three heteroatoms -- 5.3.1. Three nitrogen atoms -- 5.3.2. Two nitrogen atoms and one oxygen or sulfur atom -- 5.4. Four heteroatoms -- 6. Six-membered rings -- 6.1. One heteroatom -- 6.1.1. One nitrogen atom.
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| 650 |
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|a Heterocyclic chemistry.
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| 650 |
|
7 |
|a Heterocyclic chemistry.
|2 fast
|0 (OCoLC)fst00955735
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| 700 |
1 |
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|a Scriven, Eric F. V.
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| 700 |
1 |
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|a Ramsden, Christopher A.,
|d 1946-
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| 776 |
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|c Original
|z 0443193169
|z 9780443193163
|w (OCoLC)1336986264
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|u https://sciencedirect.uam.elogim.com/science/bookseries/00652725/140
|z Texto completo
|
