Gene-environment interactions in birth defects and developmental disorders /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Lipinski, Robert J., Krauss, Robert S.
Formato: eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2023.
Colección:Current topics in developmental biology ; v. 152.
Temas:
Abnormalities, Human > Genetic aspects.
Abnormalities, Human > Environmental aspects.
Environmentally induced diseases.
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Gene-Environment Interactions in Birth Defects and Developmental Disorders
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: Gene-environment interactions in birth defect etiology: Challenges and opportunities
  • 1. Introduction
  • 2. Defining the genetic landscape of birth defect etiology
  • 2.1. Syndromic birth defects
  • 2.2. Nonsyndromic birth defects
  • 3. Elucidating the environmental landscape of birth defect etiology
  • 3.1. Human teratogens
  • 3.2. Environmental risk factors
  • 3.3. High-throughput predictive approaches
  • 4. Gene-environment interactions
  • 4.1. Gene-environment interactions in infectious diseases
  • 4.2. Gene-environment interactions in cancer
  • 5. Model systems for the study of gene-environment interactions in birth defects
  • 5.1. Invertebrate models
  • 5.2. Zebrafish
  • 5.3. Mice
  • 5.3.1. Gene-environment interactions in mouse models of HPE
  • 5.3.2. Gene-environment interactions in mouse models of CHD
  • 5.4. Human systems
  • 6. Future directions: Potential mechanisms of gene-environment interaction
  • 6.1. Epigenetics and DNA methylation
  • 7. Concluding remarks
  • Acknowledgments
  • References
  • Chapter Two: Transgenerational inheritance and its modulation by environmental cues
  • 1. Introduction
  • 2. Epigenetic mechanisms of inheritance
  • 3. Substrates for epigenetic inheritance
  • 3.1. Epigenetic dynamics during germ cells development
  • 3.2. Windows of susceptibility
  • 4. Evidence for environmentally-induced epigenetic inheritance in mammals
  • 4.1. Manufactured chemicals
  • 4.2. Metals
  • 4.3. Diet
  • 4.4. Substances use and abuse
  • 5. Harnessing in vitro models for gene-environment interaction studies
  • 5.1. Current limitations to TEI studies in mammals
  • 5.2. In vitro germ cell models
  • 6. Conclusion and future challenges
  • References
  • Chapter Three: Gene-alcohol interactions in birth defects
  • 1. Introduction
  • 2. FASD background and prevalence
  • 3. What are multifactorial interactions in birth defects?
  • 4. Evidence for gene-alcohol interactions
  • 4.1. Human studies
  • 4.1.1. Twin studies
  • 4.1.2. Human gene-disease association studies
  • 4.1.2.1. Alcohol metabolizing genes
  • 4.1.2.2. Chromosome architecture genes
  • 4.2. Animal model studies
  • 4.2.1. Strain differences
  • 4.2.1.1. Mouse
  • 4.2.1.2. Chicken
  • 4.2.1.3. Zebrafish
  • 4.2.2. Forward genetics
  • 4.2.3. Reverse genetics, candidate-based studies
  • 4.2.3.1. Retinoic acid signaling
  • 4.2.3.2. Hedgehog signaling pathway
  • 4.2.3.3. Ciliary genes
  • 4.2.3.4. Nitric oxide pathway
  • 4.2.3.5. Growth factor and planar cell polarity pathways
  • 4.2.4. Non-genetic factors in FASD
  • 4.2.4.1. Environmental toxicants
  • 4.2.4.2. Cannabinoids
  • 5. Concluding remarks
  • Acknowledgment
  • References
  • Chapter Four: The role of genes and environment in the etiology of congenital diaphragmatic hernias
  • 1. Introduction
  • 2. Diaphragm development

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