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SCIDIR_on1366220366 |
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OCoLC |
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20231120010724.0 |
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m o d |
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230202s2023 mau o 000 0 eng d |
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|a YDX
|b eng
|c YDX
|d OPELS
|d EBLCP
|d OCLCQ
|d OCLCF
|d OCLCQ
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| 020 |
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|a 9780128201633
|q (electronic bk.)
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| 020 |
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|a 0128201630
|q (electronic bk.)
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| 020 |
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|z 9780128201572
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| 020 |
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|z 0128201576
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| 035 |
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|a (OCoLC)1366220366
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| 050 |
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4 |
|a RB155
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| 082 |
0 |
4 |
|a 616.042
|2 23
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| 245 |
0 |
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|a Gene-environment interactions in birth defects and developmental disorders /
|c edited by Robert J. Lipinski, Robert Krauss.
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| 260 |
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|a Cambridge, MA :
|b Academic Press,
|c 2023.
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| 300 |
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|a 1 online resource
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| 490 |
1 |
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|a Current topics in developmental biology ;
|v v. 152
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| 588 |
0 |
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|a Print version record.
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| 505 |
0 |
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|a Intro -- Gene-Environment Interactions in Birth Defects and Developmental Disorders -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Gene-environment interactions in birth defect etiology: Challenges and opportunities -- 1. Introduction -- 2. Defining the genetic landscape of birth defect etiology -- 2.1. Syndromic birth defects -- 2.2. Nonsyndromic birth defects -- 3. Elucidating the environmental landscape of birth defect etiology -- 3.1. Human teratogens -- 3.2. Environmental risk factors -- 3.3. High-throughput predictive approaches -- 4. Gene-environment interactions
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| 505 |
8 |
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|a 4.1. Gene-environment interactions in infectious diseases -- 4.2. Gene-environment interactions in cancer -- 5. Model systems for the study of gene-environment interactions in birth defects -- 5.1. Invertebrate models -- 5.2. Zebrafish -- 5.3. Mice -- 5.3.1. Gene-environment interactions in mouse models of HPE -- 5.3.2. Gene-environment interactions in mouse models of CHD -- 5.4. Human systems -- 6. Future directions: Potential mechanisms of gene-environment interaction -- 6.1. Epigenetics and DNA methylation -- 7. Concluding remarks -- Acknowledgments -- References
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| 505 |
8 |
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|a Chapter Two: Transgenerational inheritance and its modulation by environmental cues -- 1. Introduction -- 2. Epigenetic mechanisms of inheritance -- 3. Substrates for epigenetic inheritance -- 3.1. Epigenetic dynamics during germ cells development -- 3.2. Windows of susceptibility -- 4. Evidence for environmentally-induced epigenetic inheritance in mammals -- 4.1. Manufactured chemicals -- 4.2. Metals -- 4.3. Diet -- 4.4. Substances use and abuse -- 5. Harnessing in vitro models for gene-environment interaction studies -- 5.1. Current limitations to TEI studies in mammals
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| 505 |
8 |
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|a 5.2. In vitro germ cell models -- 6. Conclusion and future challenges -- References -- Chapter Three: Gene-alcohol interactions in birth defects -- 1. Introduction -- 2. FASD background and prevalence -- 3. What are multifactorial interactions in birth defects? -- 4. Evidence for gene-alcohol interactions -- 4.1. Human studies -- 4.1.1. Twin studies -- 4.1.2. Human gene-disease association studies -- 4.1.2.1. Alcohol metabolizing genes -- 4.1.2.2. Chromosome architecture genes -- 4.2. Animal model studies -- 4.2.1. Strain differences -- 4.2.1.1. Mouse -- 4.2.1.2. Chicken -- 4.2.1.3. Zebrafish
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| 505 |
8 |
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|a 4.2.2. Forward genetics -- 4.2.3. Reverse genetics, candidate-based studies -- 4.2.3.1. Retinoic acid signaling -- 4.2.3.2. Hedgehog signaling pathway -- 4.2.3.3. Ciliary genes -- 4.2.3.4. Nitric oxide pathway -- 4.2.3.5. Growth factor and planar cell polarity pathways -- 4.2.4. Non-genetic factors in FASD -- 4.2.4.1. Environmental toxicants -- 4.2.4.2. Cannabinoids -- 5. Concluding remarks -- Acknowledgment -- References -- Chapter Four: The role of genes and environment in the etiology of congenital diaphragmatic hernias -- 1. Introduction -- 2. Diaphragm development
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| 650 |
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0 |
|a Abnormalities, Human
|x Genetic aspects.
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| 650 |
|
0 |
|a Abnormalities, Human
|x Environmental aspects.
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| 650 |
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0 |
|a Environmentally induced diseases.
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| 650 |
|
7 |
|a Abnormalities, Human
|x Environmental aspects.
|2 fast
|0 (OCoLC)fst00794456
|
| 650 |
|
7 |
|a Abnormalities, Human
|x Genetic aspects.
|2 fast
|0 (OCoLC)fst00794460
|
| 650 |
|
7 |
|a Environmentally induced diseases.
|2 fast
|0 (OCoLC)fst00913560
|
| 655 |
|
0 |
|a Electronic books.
|
| 700 |
1 |
|
|a Lipinski, Robert J.
|
| 700 |
1 |
|
|a Krauss, Robert S.
|
| 776 |
0 |
8 |
|c Original
|z 0128201576
|z 9780128201572
|w (OCoLC)1336460116
|
| 776 |
0 |
8 |
|i Print version:
|t Gene-environment interactions in birth defects and developmental disorders
|z 9780128201572
|w (OCoLC)1355056346
|
| 830 |
|
0 |
|a Current topics in developmental biology ;
|v v. 152.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/00702153/152
|z Texto completo
|
