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00000cam a22000007i 4500 |
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SCIDIR_on1366057953 |
| 003 |
OCoLC |
| 005 |
20231120010724.0 |
| 006 |
m o d |
| 007 |
cr cnu---unuuu |
| 008 |
230205t20232023mau o 000 0 eng d |
| 040 |
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|a YDX
|b eng
|e rda
|c YDX
|d OPELS
|d EBLCP
|d OCLCQ
|d YDX
|d OCLCF
|d OCLCQ
|d OCLCO
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| 020 |
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|a 9780443158216
|q electronic book
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|a 0443158215
|q electronic book
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|z 9780443158209
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|z 0443158207
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|a (OCoLC)1366057953
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| 050 |
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4 |
|a QD431.A3
|b S43 2023
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| 060 |
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4 |
|a QU 55
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| 082 |
0 |
4 |
|a 572.6
|2 23/eng/20230411
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| 082 |
0 |
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|a 612.4
|2 23/eng/20230208
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| 245 |
0 |
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|a Secretory Proteins /
|c edited by Rossen Donev.
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| 250 |
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|a First edition.
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| 264 |
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1 |
|a London ;
|a San Diego, CA :
|b Academic Press, an imprint of Elsevier,
|c 2023.
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| 264 |
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4 |
|c �2023
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| 300 |
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|a 1 online resource.
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| 336 |
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|a text
|b txt
|2 rdacontent
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| 337 |
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|a computer
|b c
|2 rdamedia
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| 338 |
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|a online resource
|b cr
|2 rdacarrier
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| 490 |
1 |
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|a Advances in protein chemistry and structural biology ;
|v v. 133
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| 505 |
0 |
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|a Intro -- Secretory Proteins -- Copyright -- Contents -- Contributors -- Chapter One: Proprotein convertases regulate trafficking and maturation of key proteins within the secretory pathway -- 1. Introduction -- 2. Basic PCs -- 2.1. Biochemistry -- 2.1.1. Consensus sequence -- 2.1.2. Cellular localization and organ expression -- 2.1.3. Inhibitors -- 2.2. Structure of basic proprotein convertases -- 2.3. Cellular substrates -- 2.3.1. Pro-hormones -- 2.3.2. Neuropeptides -- 2.3.3. Growth factors -- 2.3.4. Extracellular matrix (ECM)-related proteins -- 2.3.5. Other PCs substrates
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| 505 |
8 |
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|a 2.3.6. PCs as biochemistry tools -- 2.4. Pathogen substrates -- 2.4.1. Viruses -- 2.4.2. Bacteria toxins of anthrax -- 3. SKI-1/S1P -- 3.1. Biochemistry -- 3.1.1. Cellular localization and organ expression -- 3.1.2. Inhibitors -- 3.1.3. Consensus sequence -- 3.2. Structure -- 3.3. Cellular substrates -- 3.3.1. Transcription factors -- 3.3.2. GlcNAc-phosphotransferase -- 3.3.3. Pro-renin receptor -- 3.3.4. Fam20C -- 3.4. Pathogen substrates -- 3.4.1. Mammarenaviruses -- 3.4.2. Bunyaviruses -- 3.4.3. Other viruses -- 3.4.3.1. SARS-CoV-2 -- 4. PCSK9 -- 5. Conclusions -- Acknowledgments -- References
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| 505 |
8 |
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|a Chapter Two: Exploring the macromolecules for secretory pathway in cancer disease -- 1. Introduction -- 2. Secretory proteins -- 2.1. Role of secreted proteins in tumor cell proliferation and survival -- 2.2. Effect of secretory proteins on tumor cell motility and metastasis -- 2.3. Pathways associated with secretory proteins -- 3. The cancer secretome -- 4. Methods for analyzing secretory proteins -- 4.1. Genome-based computational prediction -- 4.2. Proteomic approaches -- 4.3. Gel-based proteomics approach -- 4.4. Gel-free MS-based technologies -- 4.5. SELDI-TOF-MS -- 5. Tumor cell secretome
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| 505 |
8 |
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|a 5.1. Secretome in breast cancers -- 6. Effect of therapy-induced tumor secretome on tumor microenvironment -- 7. Cancer secretome from heterotypic cells -- 8. The angiogenesis-derived secretome -- 8.1. Secretome from angiogenesis -- 9. Conclusion -- Acknowledgment -- References -- Chapter Three: Current and emerging biomarkers in ovarian cancer diagnosis -- CA125 and beyond -- 1. Introduction -- 2. Ovarian cancer and its pathogenesis -- 2.1. Genetic drivers of ovarian cancer -- 2.2. Ovarian cancer classification and histopathology -- 2.3. Molecular pathways involved in the development of OC
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| 505 |
8 |
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|a 3. Challenges/limitations associated with OC diagnosis -- 4. Molecular diagnosis of OC -- 4.1. Secretory protein biomarkers in the diagnosis and prognosis of OC -- 4.1.1. Cancer antigen 125 or carbohydrate antigen 125 (CA125) -- 4.1.2. Human epididymis secretory protein 4 (HE4) -- 4.1.3. Osteopontin (OPN) -- 4.1.4. Kallikreins (KLKs) -- 4.1.5. Vascular endothelial growth factor (VEGF) -- 4.1.6. Human Prostasin (PSN) -- 4.1.7. Transthyretin (TTR) -- 4.1.8. Risk of ovarian malignancy algorithm (ROMA) -- 4.2. Emerging potential of non-protein secretory biomarkers for OC detection -- 4.2.1. microRNAs
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| 588 |
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|a Description based on online resource; title from digital title page (viewed on April 11, 2023).
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| 650 |
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0 |
|a Proteins
|x Secretion.
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| 650 |
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0 |
|a Glands.
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| 650 |
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2 |
|a Proteins
|x Periodicals.
|
| 650 |
|
6 |
|a Prot�eines
|0 (CaQQLa)201-0008150
|x S�ecr�etion.
|0 (CaQQLa)201-0379866
|
| 650 |
|
6 |
|a Glandes.
|0 (CaQQLa)201-0040771
|
| 650 |
|
7 |
|a Glands
|2 fast
|0 (OCoLC)fst00943015
|
| 650 |
|
7 |
|a Proteins
|x Secretion
|2 fast
|0 (OCoLC)fst01079755
|
| 655 |
|
0 |
|a Electronic books.
|
| 700 |
1 |
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|a Donev, Rossen,
|e editor.
|
| 776 |
0 |
8 |
|i ebook version :
|z 9780443158216
|
| 776 |
0 |
8 |
|c Original
|z 0443158207
|z 9780443158209
|w (OCoLC)1345221646
|
| 776 |
0 |
8 |
|i Print version:
|t Secretory Proteins
|z 0443158207
|w (OCoLC)1345221646
|
| 830 |
|
0 |
|a Advances in protein chemistry and structural biology ;
|v v. 133.
|
| 856 |
4 |
0 |
|u https://sciencedirect.uam.elogim.com/science/bookseries/18761623/133
|z Texto completo
|
