Meiosis in development and disease /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Cole, Francesca
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, an imprint of Elsevier, 2023.
Edición:First edition.
Colección:Current topics in developmental biology ; 151.
Temas:
Meiosis.
Meiosis > Therapeutic use.
Meiosis
M�eiose.
M�eiose > Emploi en th�erapeutique.
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Meiosis in Development and Disease
  • Copyright
  • Contents
  • Contributors
  • Preface
  • Chapter One: Mechanism of initiation of meiosis in mouse germ cells
  • 1. Introduction
  • 2. STRA8 plays a key role in the initiation of meiosis
  • 3. MEIOSIN interacts with STRA8 during meiotic initiation
  • 4. MEIOSIN and STRA8 direct the switch from mitosis to meiosis
  • 5. MEIOSIN together with STRA8 determines meiotic entry
  • 6. MEIOSIN and STRA8 activate meiotic prophase program
  • 7. MEIOSIN and STRA8 boost the transcription of the meiotic genes
  • 8. Sexual difference of meiotic initiation
  • 9. Evolutionary conservation and divergence in the meiotic entry system
  • 10. Conclusion
  • Acknowledgments
  • Conflict of interest statement
  • References
  • Chapter Two: Orchestrating recombination initiation in mice and men
  • 1. Introduction-Orchestrating the critical stages of recombination initiation
  • 2. Germline replication timing affects broad-scale recombination patterning
  • 3. Chromatin loop array formation and loop extrusion
  • 4. Creating an accessible local chromatin environment
  • 5. Chromatin opening meiosis-specific Pioneer Complex
  • 6. Associate putative hotspot sites in the DNA loops with the chromosomal axis
  • 6.1. DSB formation
  • 7. Facilitating efficient homology engagement and DSB repair
  • 8. PRDM9 redundant meiotic recombination initiation
  • 9. Summary
  • References
  • Chapter Three: Cancer and meiotic gene expression: Two sides of the same coin?
  • 1. Introduction
  • 1.1. Role of meiotic genes in cancer
  • 2. Global DNA demethylation
  • 3. Histone modifications
  • 4. DNA accessibility
  • 5. Higher-order of chromatin structure
  • 5.1. Topologically associated domains
  • 5.2. Distal regulatory elements
  • 5.3. R-loops
  • 6. Conclusions
  • Acknowledgments
  • Author contributions
  • References
  • Chapter Four: Phase separation in controlling meiotic chromosome dynamics
  • 1. Chromosome dynamics during meiosis
  • 2. Phase separation to form biomolecular condensates in cells
  • 3. Phase separation in controlling chromatin organization and activities
  • 4. Phase separation in meiotic recombination initiation
  • 5. Phase separation in homologous chromosome pairing
  • 5.1. DSB-independent pairing
  • 5.2. DSB-dependent pairing
  • 6. Phase separation in synapsis
  • 7. Potential phase separation in mammalian sex body formation
  • 8. Perspectives
  • Acknowledgments
  • References
  • Chapter Five: Meiotic chromosome organization and its role in recombination and cancer
  • 1. Chromatin and chromosome organization during meiosis
  • 2. Evolution of the core axis proteins and the synaptonemal complex
  • 3. Morphogenesis and remodeling of the chromosome axis
  • 4. Roles of chromosomal axis proteins in DSB and crossover formation during meiosis
  • 5. Does the chromosome axis play a role in CO interference?

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