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SCIDIR_on1362496141 |
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20231120010722.0 |
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|a YDX
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|a 0128201622
|q electronic book
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|a 9780128201626
|q (electronic bk.)
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|z 9780128201565
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|z 0128201568
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|a (OCoLC)1362496141
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|a QH605.3
|b .M45 2023
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|a QU 375
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| 082 |
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|a 571.845
|2 23/eng/20230131
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|a Meiosis in development and disease /
|c edited by Francesca Cole.
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|a First edition.
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|a Cambridge, MA :
|b Academic Press, an imprint of Elsevier,
|c 2023.
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|c �2023
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|a 1 online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
|b c
|2 rdamedia
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|a online resource
|b cr
|2 rdacarrier
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|a Current topics in developmental biology ;
|v 151
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|a Intro -- Meiosis in Development and Disease -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Mechanism of initiation of meiosis in mouse germ cells -- 1. Introduction -- 2. STRA8 plays a key role in the initiation of meiosis -- 3. MEIOSIN interacts with STRA8 during meiotic initiation -- 4. MEIOSIN and STRA8 direct the switch from mitosis to meiosis -- 5. MEIOSIN together with STRA8 determines meiotic entry -- 6. MEIOSIN and STRA8 activate meiotic prophase program -- 7. MEIOSIN and STRA8 boost the transcription of the meiotic genes
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|a 8. Sexual difference of meiotic initiation -- 9. Evolutionary conservation and divergence in the meiotic entry system -- 10. Conclusion -- Acknowledgments -- Conflict of interest statement -- References -- Chapter Two: Orchestrating recombination initiation in mice and men -- 1. Introduction-Orchestrating the critical stages of recombination initiation -- 2. Germline replication timing affects broad-scale recombination patterning -- 3. Chromatin loop array formation and loop extrusion -- 4. Creating an accessible local chromatin environment -- 5. Chromatin opening meiosis-specific Pioneer Complex
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|a 6. Associate putative hotspot sites in the DNA loops with the chromosomal axis -- 6.1. DSB formation -- 7. Facilitating efficient homology engagement and DSB repair -- 8. PRDM9 redundant meiotic recombination initiation -- 9. Summary -- References -- Chapter Three: Cancer and meiotic gene expression: Two sides of the same coin? -- 1. Introduction -- 1.1. Role of meiotic genes in cancer -- 2. Global DNA demethylation -- 3. Histone modifications -- 4. DNA accessibility -- 5. Higher-order of chromatin structure -- 5.1. Topologically associated domains -- 5.2. Distal regulatory elements
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|a 5.3. R-loops -- 6. Conclusions -- Acknowledgments -- Author contributions -- References -- Chapter Four: Phase separation in controlling meiotic chromosome dynamics -- 1. Chromosome dynamics during meiosis -- 2. Phase separation to form biomolecular condensates in cells -- 3. Phase separation in controlling chromatin organization and activities -- 4. Phase separation in meiotic recombination initiation -- 5. Phase separation in homologous chromosome pairing -- 5.1. DSB-independent pairing -- 5.2. DSB-dependent pairing -- 6. Phase separation in synapsis
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|a 7. Potential phase separation in mammalian sex body formation -- 8. Perspectives -- Acknowledgments -- References -- Chapter Five: Meiotic chromosome organization and its role in recombination and cancer -- 1. Chromatin and chromosome organization during meiosis -- 2. Evolution of the core axis proteins and the synaptonemal complex -- 3. Morphogenesis and remodeling of the chromosome axis -- 4. Roles of chromosomal axis proteins in DSB and crossover formation during meiosis -- 5. Does the chromosome axis play a role in CO interference?
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|a Description based on online resource; title from digital title page (viewed on May 08, 2023).
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| 650 |
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|a Meiosis.
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| 650 |
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|a Meiosis
|x Therapeutic use.
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| 650 |
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2 |
|a Meiosis
|0 (DNLM)D008540
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| 650 |
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6 |
|a M�eiose.
|0 (CaQQLa)201-0093331
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| 650 |
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6 |
|a M�eiose
|0 (CaQQLa)201-0093331
|x Emploi en th�erapeutique.
|0 (CaQQLa)201-0373975
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| 650 |
|
7 |
|a Meiosis
|2 fast
|0 (OCoLC)fst01015610
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| 655 |
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0 |
|a Electronic books.
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| 700 |
1 |
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|a Cole, Francesca.
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| 776 |
0 |
8 |
|i Print version:
|z 9780128201626
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| 776 |
0 |
8 |
|i Print version:
|z 0128201568
|z 9780128201565
|w (OCoLC)1331706509
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| 830 |
|
0 |
|a Current topics in developmental biology ;
|v 151.
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| 856 |
4 |
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|u https://sciencedirect.uam.elogim.com/science/bookseries/00702153/151
|z Texto completo
|
