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Bidirectional gene promoters : transcription system and chromosomal structure /
Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5'-upstream regions of gene pairs are referred to as bi-directional promoters and are though...
| Clasificación: | Libro Electrónico |
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| Autor principal: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
[Place of publication not identified] :
Elsevier,
2022.
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| Temas: | |
| Acceso en línea: | Texto completo |
MARC
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| 100 | 1 | |a Uchiumi, Fumiaki, |d 1962- | |
| 245 | 1 | 0 | |a Bidirectional gene promoters : |b transcription system and chromosomal structure / |c Fumiaki Uchiumi. |
| 264 | 1 | |a [Place of publication not identified] : |b Elsevier, |c 2022. | |
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| 505 | 0 | |a Intro -- Bidirectional Gene Promoters: Transcription System and Chromosomal Structure -- Copyright -- Contents -- Preface -- Chapter 1: Introductory Chapter: DNA Replication and Transcription -- DNA replication origin in eukaryotic cells -- Helicases that regulate transcription and DNA replication -- From the RNA world to the DNA/RNA/protein world -- Viruses and transposable elements -- Alterations in transcriptional state during the aging process -- Conclusion -- References -- Section I: Biological significances of the bidirectional transcription in eukaryotic cells | |
| 505 | 8 | |a Chapter 2: Mitochondrial function and immune response-regulating factor-encoding gene promoters -- Origin of mitochondria and endosymbiosis -- Known functions of mitochondria -- Mitochondrial dysfunction and human diseases -- Bidirectional promoters of human mitochondrial function-associated genes -- Immune responses and mitochondrial functions are dependent on each other -- Bidirectional promoters of human interferon-stimulated gene (ISG) promoters -- Glycolysis enzyme-encoding gene promoters -- Conclusion -- References -- Chapter 3: DNA repair factor-encoding gene promoters | |
| 505 | 8 | |a Slight but appropriate low levels of mutation are essential for evolution -- Classification of the DNA repair systems in mammalian cells -- Dysfunctions in the DNA repair system that cause human diseases -- Xeroderma pigmentosum (XP) and Cockayne syndrome (CS) -- Fanconi anemia (FA) -- Ataxia telangiectasia (AT) -- Bloom syndrome (BS), Rothmund-Thomson syndrome (RTS), and Werner syndrome (WS) -- Immunological diseases -- Cancer -- Neurodegenerative diseases -- Bidirectional promoters of human DNA repair factor-encoding genes | |
| 505 | 8 | |a Mitonuclear communication, telomere maintenance, and nicotinamide adenine dinucleotide (NAD+) -- DNA repair factors that localize in mitochondria -- Cross-talk between DNA repair and immunological responses -- Conclusion -- References -- Chapter 4: Regulation of non-coding RNA promoters -- From the RNA world: re-evaluation of non-coding RNAs (ncRNAs) -- Classification of ncRNAs and relationships with DNA repair, mitochondrial function, and the immune system -- The ncRNAs that may play roles in pathogenesis of age-related human diseases | |
| 505 | 8 | |a Bidirectional promoters of lncRNAs and the head-head linked genes -- ANRIL_CDKN2A (p16-encoding) -- BACE1-AS_BACE1 (overlapping) -- BDNF-AS_LIN7C -- GAS5_ZBTB37 -- HOTAIR_HOX11 (overlapping) -- NBR2_BRCA1 -- NEAT1_LOC107984338 -- SOD2 (GClnc1)_ACAT2 -- TUG1_MORC2 -- ZFAS1_ZNFX1 -- Bidirectional promoters of the miRNA host and the oppositely transcribed partner genes -- DNA replication/repair/cell cycle control: MCM7, CTDSPL -- Apoptosis and autophagy: AATK, AEN, VMP1 -- Mitochondrial functions and metabolisms: ATP5MD, PANK1, PANK2, PDE4D, SREBF2 | |
| 520 | |a Recent studies in human genetics and in silico analyses have revealed that a number of genes are head-head orientated with other genes or non-coding RNAs. The expression of regulatory element-containing 5'-upstream regions of gene pairs are referred to as bi-directional promoters and are thought to have a key role in biological regulatory mechanisms. For example, tumor suppressor protein-encoding TP53 and BRCA1 genes are head-head bound with WRAP53 and NBR2, respectively. DNA-repair factor-encoding ATM and PRKDC (DNA-PKcs) genes have bidirectional partner NPAT and MCM4, respectively. Surveillance of the human DNA database has revealed that the numbers of DNA repair/mitochondrial function/immune response-associated genes are bound with other genes that are transcribed to opposite direction. The observations may encourage us to investigate in the molecular mechanisms how DNA repair/mitochondrial function/immune response-associated genes are regulated by bidirectional promoters. Not only protein-coding genes, but also quite a few ncRNAs, which play important roles in various cellular events, are transcribed under the regulation of the bidirectional promoters. More importantly, we know that dysregulation in the promoter activity and transcription initiation of genes might cause human diseases. | ||
| 650 | 0 | |a Promoters (Genetics) | |
| 650 | 6 | |a Promoteurs (G�en�etique) |0 (CaQQLa)201-0124184 | |
| 650 | 7 | |a Promoters (Genetics) |2 fast |0 (OCoLC)fst01078913 | |
| 655 | 0 | |a Electronic books. | |
| 776 | 0 | 8 | |i Print version: |z 0128187875 |z 9780128187876 |w (OCoLC)1290380829 |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/book/9780128187876 |z Texto completo |