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Ion transport and membrane interactions in vascular health and disease /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Cambridge, MA :
Academic Press,
2022.
|
| Colección: | Current topics in membranes ;
v. 90. |
| Temas: | |
| Acceso en línea: | Texto completo Texto completo |
MARC
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| 020 | |a 0323997899 |q (electronic bk.) | ||
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| 082 | 0 | 4 | |a 571.64 |2 23 |
| 245 | 0 | 0 | |a Ion transport and membrane interactions in vascular health and disease / |c Edited by Michael Sturek. |
| 260 | |a Cambridge, MA : |b Academic Press, |c 2022. | ||
| 300 | |a 1 online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 490 | 1 | |a Current topics in membranes ; |v v. 90 | |
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references. | ||
| 505 | 0 | |a Intro -- Ion Transport and Membrane Interactions in Vascular Health and Disease -- Copyright -- Contents -- Contributors -- Preface -- Acknowledgments -- Chapter One: Introduction to ion transport and membrane interactions in vascular health and disease -- 1. Vascular specificity in health and disease -- 2. Metabolic disease milieu and experimental approaches and models -- 3. Snapshot of ion transport and membrane interactions -- 4. Conclusions and future directions -- Acknowledgments -- References -- Chapter Two: An unexpected effect of risperidone reveals a nonlinear relationship between cytosolic Ca uptake -- 1. Introduction -- 2. Materials and methods -- 2.1. Materials and compounds -- 2.2. Cell culture and preparation -- 2.3. Transfection -- 2.4. Buffers and solutions -- 2.5. Loading with fura-2/am -- 2.6. Genetically-encoded fluorescent sensors -- 2.7. Microscopes and acquisition -- 2.8. Data analysis -- 2.9. Statistics -- 3. Results -- 3.1. Risperidone inhibited cytosolic Ca transients -- 3.2. The effect of risperidone on endothelial Ca was exclusively due to its inhibitory effect on histamine-triggered sign ... -- 3.3. Risperidone inhibited histamine-induced mitochondrial Ca signals -- 3.4. Risperidone appears more potent in preventing histamine-induced mitochondrial Ca elevations -- 3.5. Using various concentrations of risperidone, a linear cytosolic Ca elevation upon histamine was achieved -- 3.6. The correlation between cytosolic and mitochondrial Ca elevations is biphasic but linear after a certain threshold -- 4. Discussion -- Conflict of interest -- Acknowledgments -- Author contributions -- References -- Chapter Three: Regulation of exosome release by lysosomal acid ceramidase in coronary arterial endothelial cells: Role of ... -- 1. Introduction -- 2. Materials and methods. | |
| 505 | 8 | |a 2.1. Isolation and culture of CAECs from mouse coronary artery -- 2.2. GCaMP3 Ca imaging -- 2.3. Isolation of lysosomes from CAECs -- 2.4. Whole-lysosome patch clamp recording -- 2.5. Structured illumination microscopy -- 2.6. Nanoparticle tracking analysis -- 2.7. Dynamic analysis of lysosome movement in CAECs -- 2.8. Statistical analysis -- 3. Results -- 3.1. Elevation of exosome release and reduction of lysosome-MVB interaction in CAECs lacking Asah1 gene -- 3.2. Inhibition of exosome release from CAECs lacking Asah1 gene by sphingosine -- 3.3. Regulation of lysosome trafficking and lysosome-MVB interaction by ML-SA1 and sphingosine in CAECs -- 3.4. Characterization of TRPML channels in CAECs -- 3.5. Blockade of TRPML1 channel by Asah1 gene deletion in CAECs -- 3.6. Rescue of TRPML1 channel activity by sphingosine in CAECs lacking Asah1 gene -- 3.7. Contribution of dynein activity to lysosomal regulation of exosome release in CAECs -- 4. Discussion -- References -- Chapter Four: Vascular CaV1.2 channels in diabetes -- 1. Introduction -- 2. General L-type Ca channel CaV1.2 structure -- 3. Regulation of vascular CaV1.2 channels -- 3.1. Splice variants -- 3.2. Phosphorylation -- 4. Effects of hyperglycemia on CaV1.2 -- 5. Mechanisms of hyperglycemia-induced regulation of vascular CaV1.2 channels -- 5.1. PKA -- 5.2. AC5 -- 5.3. P2Y11 -- 5.4. A-kinase anchoring proteins (AKAPs) -- 6. Conclusions and future directions -- Acknowledgments -- References -- Chapter Five: Multiphasic changes in smooth muscle Ca transporters during the progression of coronary atherosclerosis -- 1. Overview of vascular smooth muscle intracellular Ca regulation in health -- 2. Smooth muscle phenotypic modulation and [Ca]i handling alterations -- 3. Metabolic syndrome ``milieu�� -- 4. Atherogenesis. | |
| 505 | 8 | |a 5. Function/dysfunction of Ca transporters during coronary atherosclerosis progression in swine -- 6. SERCA stimulation induces coronary smooth muscle proliferation in early atherosclerosis -- 6.1. Methods -- 6.1.1. Organ culture of epicardial conduit coronary arteries -- 6.1.2. Proliferation assay -- 6.1.3. Immunohistochemistry -- 6.1.4. Statistical analysis -- 6.2. Results -- 7. Similarity of swine and human coronary atherosclerosis and smooth muscle Ca signaling -- 8. Multiphasic model of coronary smooth muscle Ca transporter regulation in atherosclerosis -- 9. Conclusions and future directions -- Acknowledgments -- References -- Chapter Six: Specificity of Ca channel modulation in atherosclerosis and aerobic exercise training -- 1. General information on main types of K channels -- 1.1. Voltage-gated K channels (Kv) -- 1.2. ATP-sensitive K channels (KATP) -- 1.3. Inward rectifier K channels (Kir) -- 1.4. Calcium-activated K channels (BKCa) -- 2. Physiological roles of KCa channels -- 3. Effects of chronic exercise on reduction of cardiovascular disease and underlying K channel adaptations -- 4. Conclusions and future directions -- Acknowledgments -- References -- Chapter Seven: K+ channels in the coronary microvasculature of the ischemic heart -- 1. Introduction -- 2. Porcine model of ischemic heart disease -- 3. Role of K channels in basal active tone of arterioles from ischemic myocardium -- 4. Kv channels in arteriolar smooth muscle cells of ischemic myocardium -- 5. BKCa channels in arteriolar smooth muscle cells of ischemic myocardium -- 6. Role of additional K channel subfamilies in control of basal tone and vasodilation -- 7. Conclusion -- References. | |
| 650 | 0 | |a Ion channels. | |
| 650 | 0 | |a Membranes (Biology) | |
| 650 | 6 | |a Canaux ioniques. |0 (CaQQLa)201-0145111 | |
| 650 | 6 | |a Membranes (Biologie) |0 (CaQQLa)201-0009733 | |
| 650 | 7 | |a Ion channels |2 fast |0 (OCoLC)fst00978573 | |
| 650 | 7 | |a Membranes (Biology) |2 fast |0 (OCoLC)fst01015860 | |
| 700 | 1 | |a Sturek, Michael, |e editor. | |
| 776 | 0 | 8 | |i ebook version : |z 9780323997898 |
| 776 | 0 | 8 | |c Original |z 0323997880 |z 9780323997881 |w (OCoLC)1318990414 |
| 776 | 0 | 8 | |i Print version: |t ION TRANSPORT AND MEMBRANE INTERACTIONS IN VASCULAR HEALTH AND DISEASE. |d [S.l.] : ELSEVIER ACADEMIC PRESS, 2022 |z 0323997880 |w (OCoLC)1318990414 |
| 830 | 0 | |a Current topics in membranes ; |v v. 90. | |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/science/bookseries/10635823/90 |z Texto completo |
| 856 | 4 | 0 | |u https://sciencedirect.uam.elogim.com/bookseries/current-topics-in-membranes/vol/90/suppl/C |z Texto completo |