Advances in genetics. Volume 109 /

Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD an...

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Detalles Bibliográficos
Clasificación:Libro Electrónico
Formato: Electrónico eBook
Idioma:Inglés
Publicado: Amsterdam : Academic Press, 2022.
Temas:
Genetics.
G�en�etique.
genetics.
Genetics
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Advances in Genetics
  • Copyright
  • Contents
  • Contributors
  • Chapter One: RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms
  • 1. Introduction
  • 2. Chi is more frequent in many bacterial species and E. coli phages and plasmids than in E. coli itself
  • 3. Chi is active in ``foreign�� species
  • 4. Is Chi ``over-represented�� in E. colis genome?
  • 4.1. Nucleotides are not randomly arranged in the E. coli genome
  • 4.2. Amino acids are not quite randomly associated in E. coli proteins
  • 4.3. Codon usage is even more non-random than amino acid usage in E. coli
  • 4.4. Preferential codon usage can account for Chi�s high frequency in E. coli
  • 5. ``Chi�� sequence of S. aureus also comports with its codon usage
  • 6. Temperate phage P1 contains 50 Chi sites, likely uses them to its advantage, and appears to select for Chi as a recomb ...
  • 7. A myth: ``Chi converts RecBCD from phage destruction to DNA repair��
  • 8. An observation: RecBCD destroys DNA in E. coli only if it cannot recombine
  • 9. Mechanisms employing RecBCD that do distinguish self vs. non-self DNA
  • 10. Conclusion: Telling self from non-self is complex
  • 11. Methods of data analysis
  • Acknowledgments
  • References
  • Chapter Two: Multiple regulatory mechanisms for pH homeostasis in the gastric pathogen, Helicobacter pylori
  • 1. Introduction
  • 1.1. Two mechanisms of acid-resistance
  • 1.2. Urease activity needs to be regulated
  • 2. H. pylori reference genome, gene nomenclature and genomic diversity
  • 3. Urease function and urea supply
  • 4. Regulation of urease activities
  • 4.1. Sensors of pH changes
  • 4.2. Effectors controlling the expression of the urease gene cluster
  • 4.3. Nickel homeostasis and urease activation
  • 4.3.1. Nickel importing and exporting
  • 4.3.2. Nickel sequestrating and storage proteins
  • 4.3.3. Different pathways for nickel insertion between urease and hydrogenase
  • 4.3.4. Regulatory proteins for maintaining nickel homeostasis

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