Disorders of protein synthesis /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Donev, Rossen
Formato: eBook
Idioma:Inglés
Publicado: Cambridge, MA : Academic Press, 2022.
Colección:Advances in protein chemistry and structural biology ; 132
Temas:
Proteins > Synthesis.
Electronic books.
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • Disorders of Protein Synthesis
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Translation termination codons in protein synthesis and disease
  • 1. Ribosome fidelity and translation termination
  • 2. Nonsense mutations and the mRNA quality control
  • 3. Ribosome readthrough
  • 3.1. Mechanism, programmed readthrough and natural vs premature stop codons
  • 3.2. Readthrough-inducing compounds
  • 3.3. The determinants of readthrough
  • 3.3.1. The sequence context
  • 3.3.2. The reinserted amino acid
  • 4. Readthrough induction as a therapeutic approach for PTC suppression
  • 4.1. Cystic fibrosis
  • 4.2. Duchenne muscular dystrophy
  • 4.3. Coagulation factor deficiencies
  • 4.4. Lysosomal storage disorders
  • 5. Conclusions
  • Author contributions
  • Funding
  • Conflicts of interest
  • References
  • Chapter Two: The disturbance of protein synthesis/degradation homeostasis is a common trait of age-related neurodegenerat ...
  • 1. Introduction
  • 2. Proteostasis: The balance between synthesis, folding and degradation
  • 2.1. Protein re-folding and surveillance
  • 2.1.1. Molecular chaperones
  • 2.1.2. The unfolded protein response
  • 2.1.3. The integrated stress response
  • 2.2. Protein degradation
  • 2.2.1. The ubiquitin proteome system
  • 2.2.2. Autophagy
  • 3. The proteostasis network in the brain
  • 3.1. Evidence of aberrant proteostasis in age-related neurodegenerative diseases
  • 3.1.1. Alzheimer�s disease
  • 3.1.2. Parkinson�s disease
  • 3.1.3. Amyotrophic lateral sclerosis
  • References
  • Chapter Three: Computational and structural investigation of Palmitoyl-Protein Thioesterase 1 (PPT1) protein causing Neur ...
  • 1. Introduction
  • 2. Materials and methods
  • 2.1. Sequence and mutations retrieval
  • 2.2. Deleteriousness, stability, and conservation analysis
  • 2.3. Structural effects prediction
  • 2.4. Molecular dynamics simulation (MDS) analysis
  • 3. Results
  • 3.1. Sequence and mutations retrieval
  • 3.2. Deleteriousness, stability, and conservation analysis
  • 3.3. Structural effects prediction
  • 3.4. Molecular dynamics simulations
  • 4. Discussion
  • 5. Conclusion
  • Acknowledgment
  • Role of funding source
  • Author contributions
  • Conflict of interest
  • References
  • Chapter Four: Translation initiation and its relationship with metabolic mechanisms in cancer development, progression an ...
  • 1. Introduction
  • 2. Translation initiation and its regulation
  • 2.1. The formation of the preinitiation complex (PIC)
  • 2.2. mRNA activation by assembly with eIF4F complex and binding to the 43S PIC
  • 2.2.1. Formation of mRNA structures in 5 untranslated region (5UTR)
  • 2.3. Scanning of the mRNA-bound ribosomal complex along with the 5UTR mRNA
  • 2.4. Formation of the 80S ribosome
  • 3. The impact of translation initiation in cancer

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