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Applications of nanotechnology in drug delivery and delivery /
| Clasificación: | Libro Electrónico |
|---|---|
| Otros Autores: | |
| Formato: | Electrónico eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam :
Elsevier,
2022.
|
| Colección: | Drug discovery update
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Front Cover
- Applications of Nanotechnology in Drug Discovery and Delivery
- Copyright Page
- Contents
- List of contributors
- 1 Fundamentals, Trends and Advances in Nanotechnology
- 1 Roles of nanoparticles in drug discovery and delivery
- 1.1 Introduction
- 1.2 Types of nanoparticles
- 1.2.1 Lipid nanoparticles
- 1.2.2 Polymer-based nanoparticles
- 1.2.3 Inorganic component-based nanoparticles
- 1.3 Application of nanoparticles
- 1.3.1 Drug release profile
- 1.3.2 Gene delivery
- 1.3.3 Pulmonary delivery
- 1.3.4 Antimicrobial delivery
- 1.3.5 Brain targeting
- 1.3.6 Pharmacokinetics and biodistribution
- 1.3.7 Mucoadhesive delivery
- 1.3.8 Skin delivery
- 1.3.9 Macrophage uptake
- 1.3.10 Nanotheranostics
- 1.4 Summary and conclusion
- References
- 2 Nanoencapsulation of nutraceuticals and dietary supplements for effective delivery
- 2.1 Introduction
- 2.2 Nutraceuticals
- 2.3 Nanoencapsulation of nutraceuticals and dietary supplements
- 2.4 Nanoencapsulation techniques for nutraceuticals
- 2.4.1 Emulsification technique
- 2.4.2 Nanoprecipitation technique
- 2.4.3 Coacervation technique
- 2.5 Encapsulated nutraceuticals for drug delivery
- 2.5.1 Nanoemulsions
- 2.5.2 Polymeric nanoparticles
- 2.5.3 Magnetic nanoparticles
- 2.5.4 Nanoliposomes
- 2.5.5 Nanophytosomes
- 2.6 Conclusion
- Abbreviations
- References
- 3 Nanoformulation of antioxidant supplements
- 3.1 Introduction
- 3.2 Nanoformulations methods
- 3.2.1 Emulsion solvent evaporation method
- 3.2.2 Solvent displacement method
- 3.2.3 Supercritical fluid technology
- 3.2.4 Template synthesis method
- 3.2.5 Chemical precipitation technique
- 3.2.6 Nanoprecipitation
- 3.3 Nanoformulations for antioxidants
- 3.3.1 Natural or plant-derived nanoantioxidants
- 3.3.1.1 Nanocurcumin
- 3.3.1.2 Nanoepigallocatechin-3-gallate.
- 3.3.1.3 Nanogenistein
- 3.3.1.4 Nanoquercetin
- 3.3.1.5 Nanoresveratrol
- 3.3.1.6 Nanorosmarinic acid
- 3.3.2 Chemical and synthetic nanoantioxidants
- 3.3.2.1 Silica nanoparticles
- 3.3.2.2 Gold nanoparticles
- 3.3.2.3 Silver nanoparticles
- 3.3.2.4 Iron oxide magnetic nanoparticles
- 3.3.2.5 Cerium oxide nanoparticles
- 3.3.2.6 Dual nanoantioxidant
- 3.3.2.7 Polymeric nanoantioxidant
- 3.3.2.8 Metal nanoantioxidants
- 3.4 Antioxidants in nanomedicine
- 3.4.1 Vitamin C
- 3.4.2 Vitamin E
- 3.4.3 Beta-carotene
- 3.4.4 Selenium
- 3.5 Advantages and disadvantages of nanofomulation of antioxidant supplements
- 3.6 Future perspective and conclusion
- Abbreviations
- References
- 4 Nanophytomedicines: nature to medicines
- 4.1 Introduction
- 4.2 Nanophytomedicines
- 4.3 Therapeutic potentials of nanophytomedicine
- 4.4 Nanophytomedicines with improved target binding ability
- 4.5 Nanophytomedicines and their oral bioavailability
- 4.6 Nanophytomedicine with improved safety
- 4.7 Toxicity of nanophytomedicine
- 4.8 Regulatory aspects and ethical issues associated with nanophytomedicine
- 4.9 Challenges encountered in nanophytomedicine
- 4.10 Current progress and future prospects
- 4.11 Conclusion
- References
- 5 Characterization of nanoparticles: methods and techniques
- 5.1 Introduction
- 5.2 Differential scanning calorimetry
- 5.3 Fourier transform infrared spectroscopy
- 5.4 Scanning electron microscopy
- 5.5 Transmission electron microscopy
- 5.6 X-Ray diffraction
- 5.7 Encapsulation efficiency, drug-loading capacity, and percentage of recovery
- 5.8 Topical nanoparticle strategies
- 5.9 Drug release studies of nanoparticles
- 5.9.1 Drug release study of nanoparticles for oral dosage forms
- 5.9.2 Drug release study of nanoparticles for topical dosage forms
- 5.10 Solubility of nanoparticles.
- 5.11 Toxicity effects of nanoparticles
- 5.11.1 In vitro toxicity effect
- 5.11.1.1 In vivo toxicity effect for topical administration of nanoparticles
- 5.11.1.2 In vivo toxicity effects for oral administration of nanoparticles
- 5.12 Stability enhancement of nanoparticles
- 5.13 Future projection and conclusion
- References
- 2 Nanopharmaceutical Applications In Clinical Practice
- 6 Applications of nanotechnology in pharmaceutical products
- 6.1 Introduction
- 6.2 Comparison of traditional and nanodrug delivery
- 6.2.1 Essentials of drug delivery system
- 6.2.2 Conventional versus novel drug delivery system
- 6.2.3 Carrier-based drug delivery system
- 6.2.4 Nanodrug delivery system as a carrier-based drug delivery system
- 6.3 Pharmaceutical products through nanotechnology
- 6.3.1 Classification of nanopharmaceutical products
- 6.3.1.1 Nanomaterials
- 6.3.1.2 Nanodevices
- 6.4 Applications of nanotechnology in pharmaceutical processes
- 6.4.1 Drug delivery
- 6.4.2 Gene therapy
- 6.4.3 Medical diagnosis
- 6.4.4 Drug discovery
- 6.4.5 Other novel applications
- 6.5 Challenges in nanotechnology-based drug delivery system
- 6.6 Conclusion and future perspectives
- References
- 7 Advances in nanotechnology for drug discovery and design
- 7.1 Introduction
- 7.2 Nanomaterials, nanotechnology, and nanobiotechnology
- 7.2.1 Nanomaterials
- 7.2.2 Nanotechnology
- 7.2.3 Nanobiotechnology
- 7.3 Role of nanotechnology and nanobiotechnology in biomedicine
- 7.3.1 Biopolymer nanoparticles
- 7.3.2 Protein and polysaccharide nanoparticles
- 7.3.3 Liposomes
- 7.3.4 Polymeric micelles
- 7.3.5 Nanocrystals
- 7.3.6 Quantum dots
- 7.3.7 Dendrimers
- 7.3.8 Metallic nanoparticles
- 7.4 Hurdles and challenges
- 7.5 Future perspectives
- 7.6 Summary and conclusion
- References
- Further reading.
- 8 Nanomedicine for diabetes mellitus management
- 8.1 Introduction
- 8.2 Type 1 diabetes mellitus and nanomedicine
- 8.3 Type 2 diabetes mellitus and nanomedicine
- 8.4 Insulin delivery and nanotechnology
- 8.4.1 Polymeric nanoparticles
- 8.4.2 Ceramic nanoparticles
- 8.4.3 Polymeric micelles
- 8.4.4 Dendrimers
- 8.4.5 Liposomes
- 8.4.6 Other nanoparticles
- 8.5 Nanopumps
- 8.6 Insulin delivery via inhalation
- 8.7 Transplanted pancreatic islets nanoencapsulation
- 8.8 Biological microelectromechanical systems for insulin delivery
- 8.9 Nanotechnology in noninsulin remedy
- 8.9.1 Artificial pancreas
- 8.9.2 Nanopore immunoisolation tools
- 8.9.3 Nanorobotics
- 8.10 Nanotechnology applications in the management of diabetes-related complications
- 8.10.1 Nanotechnology in diabetic retinopathy
- 8.10.2 Nanotechnology in diabetes-induced foot ulcers
- 8.10.3 Nanotechnology in other diabetes-associated complications
- 8.11 Advantages of using nanotechnology in diabetes mellitus management
- 8.12 Limitations in using nanotechnology in diabetes mellitus management
- 8.13 Conclusion
- References
- 9 Nanotechnological application of peptide- and protein-based therapeutics
- 9.1 Introduction
- 9.2 Benefits of peptide and protein therapeutics in biomedicine
- 9.3 Challenges with peptide- and protein-based therapeutics
- 9.4 Excipients used in synthesis of protein and peptide nanoparticles
- 9.4.1 Gliadin
- 9.4.2 Milk protein
- 9.4.3 Legumin
- 9.4.4 Elastin
- 9.4.5 Albumin
- 9.4.6 Gelatin
- 9.4.7 Zein
- 9.4.8 Soy protein
- 9.5 Therapeutic and diagnostic applications of protein-based therapeutics nanomaterials
- 9.5.1 Therapeutic application
- 9.5.1.1 Ocular disease applications
- 9.5.1.2 Application in cancer treatment
- 9.5.1.3 Applications of nanoparticles of protein-based therapeutics in treatment of other diseases.
- 9.5.2 Diagnostic applications
- 9.5.2.1 Magnetic nanoparticles
- 9.5.2.2 Carbon nanotubes and gold nanoparticles
- 9.5.2.3 Other diagnostics using protein-based therapeutic nanoparticles
- 9.6 Improving stability using protein-based therapeutics nanoparticles
- 9.6.1 Physical stability enhancement
- 9.6.2 Biological stability improvement
- 9.7 Evaluation parameters and formulation techniques for protein/peptide nanoparticles
- 9.7.1 Emulsification method
- 9.7.2 Desolvation method
- 9.7.3 Electrospray method
- 9.7.4 Complex coacervation method
- 9.8 Biomedical applications of nanoparticles of proteins and peptides
- 9.8.1 Routes
- 9.8.1.1 Oral route
- 9.8.1.2 Blood-brain barrier routes
- 9.8.1.3 Nasal route
- 9.8.1.4 Pulmonary route
- 9.8.2 Antibiotics
- 9.8.3 Delivery of nonviral gene
- 9.8.4 Immunological adjuvant
- 9.8.5 Treatment of diseases
- 9.9 Concerns about peptide- and protein-based nanoparticles
- 9.10 Future prospects
- 9.11 Conclusion
- Abbreviations
- References
- 10 Nanodrug delivery systems in cancer therapy
- 10.1 Introduction
- 10.2 Currently available conventional cancer therapy
- 10.3 Drug delivery systems
- 10.4 Drug carriers
- 10.4.1 Types of drug carriers
- 10.4.1.1 Microspheres
- 10.4.1.2 Polymeric micelles
- 10.4.1.3 Liposomes
- 10.4.1.4 Nanodiamonds
- 10.4.1.5 Nanofibers
- 10.5 Protein nanoparticles
- 10.6 Anticancer nanoparticle drugs
- 10.7 Application of nanodrug delivery systems
- 10.8 Drawbacks of using nanodrug delivery
- 10.9 Conclusion and future perspectives
- References
- 11 Nanotechnology interventions in neuroscience: current perspectives and strategies
- 11.1 Introduction
- 11.2 Nanotechnology in neuroimaging
- 11.3 Nanotechnology in neurodiagnostic
- 11.4 Nanotechnology in neurological devices.