Cargando…
Human gonadotropins /
| Clasificación: | Libro Electrónico |
|---|---|
| Autor principal: | |
| Otros Autores: | |
| Formato: | eBook |
| Idioma: | Inglés |
| Publicado: |
Amsterdam, Netherlands :
Elsevier,
2022.
|
| Temas: | |
| Acceso en línea: | Texto completo |
Tabla de Contenidos:
- Cover
- Title
- Copyright
- Contents
- List of Contributors
- Foreword
- Introduction
- Chapter 1
- Evolution of LH and FSH from a common gonadotropic ancestral hormone
- References
- Chapter 2
- Evolution of CG and development of humans
- References
- Chapter 3
- Structure of FSH
- References
- Chapter 4
- Structure of LH
- References
- Chapter 5
- Structure of hCG
- References
- Chapter 6
- Structure of multiple forms of hCG
- References
- Chapter 7
- Synthesis of the gonadotropins
- References
- Chapter 8
- Function of gonadotropin releasing hormone and inhibin
- Gonadotropin releasing hormone
- Neuroanatomy
- GnRH structure
- GnRH secretion
- Control/regulation of GnRH
- Regulation of GnRH by neuronal inputs
- KNDy neurons
- Other neuropeptides
- Regulation of GnRH by gonadal feedback
- Regulation of GnRH by other regulating factors
- Clinical application of GnRH
- GnRH in the ovary
- GnRH in the endometrium
- Inhibin
- Structure
- Receptors
- Production and inhibin expression in females
- Production and expression in males
- Summary
- References
- Chapter 9
- Function of hormone hCG
- Synthesis and maintenance of hemochorial placentation
- Progesterone production by corpus luteum
- Suppression of myometrial contractions during pregnancy
- Suppression of maternal macrophages during pregnancy
- Controlling blastocyst implantation
- hCG role preimplantation preparation of the endometrium
- New observations
- Fetal hCG and fetal organs
- References
- Chapter 10
- Function of hyperglycosylated hCG and extravillous cytotrophoblast hCG
- References
- Chapter 11
- Degradation of hCG
- References
- Chapter 12
- Gonadotropin immunoassays: antibodies and standards for hCG, LH, and FSH
- Reference
- Chapter 13
- Genetics of the gonadotropins
- Genetics of FSH.
- Genetics of the hCG/LH gene cluster
- References
- Chapter 14
- Gonadotropins and steroidogenesis
- Estrogens and progestogens
- Sex steroid synthesis by the ovary
- Sex steroid synthesis in pregnancy
- Functions of sex steroids
- Sex steroid functions in the menstrual cycle and pregnancy
- Male steroidogenesis
- Functions of androgens in males
- Functions of estrogens males
- Further reading
- Chapter 15
- Gonadotropins and female reproduction
- Follicular maturation and selection
- Ovulation and luteinization
- Meiosis
- Preparation of the follicle for ovulation
- Ovulation
- Luteinization
- Propulsion of oocyte in the fallopian tube
- Fertilization
- Morula and blastocyst formation
- Twins and multiple pregnancies
- References
- Further reading
- Chapter 16
- Male reproduction: sperm formation and activation
- Spermatogenesis 1: mitotic proliferation
- Spermatogenesis 2: meiotic division
- Spermatogenesis 3: cytodifferentiation and packaging of sperm cells
- Endocrine control of spermatogenesis
- Maturation of spermatozoa
- Seminal fluids
- Sperm activation
- Spermatozoa capacitation
- Acrosome reaction
- References
- Chapter 17
- Adrenarche and menarche in girls and adrenarche and puberty in boys
- Adrenarche in girls
- Menarche
- The physiology of starting the menstrual cycle
- Adrenarche in boys
- Puberty in boys
- The physiology of the commencement of puberty
- References
- Chapter 18
- Function of the luteinizing hormone/chorionic gonadotropin receptor
- Introduction
- LHCGR gene and protein structure
- Physiological functions of LH via the LHCGR
- Signaling pathways
- Signal transduction in the testes
- Signal transduction in the ovary
- Differential signaling by LH and hCG
- Receptor di/oligomers
- Receptor internalization and downregulation
- Mutations and polymorphisms in LHCGR.
- Extragonadal expression of LHCGR
- Concluding remarks
- References
- Chapter 19
- Function of folllicle stimulating hormone and the follicle stimulating hormone receptor
- Follicle stimulating hormone (FSH)
- Neuroanatomy
- Structure of FSH molecule and FSH receptor
- Control/regulation of FSH
- Regulation of FSH by GnRH
- Regulation of FSH by gonadal feedback
- Regulation of FSH by other regulating factors
- FSH expression from fetal development across the lifespan
- Role of FSH in the menstrual cycle and folliculogenesis
- FSH in spermatogenesis
- Clinical application of FSH
- Chapter summary
- References
- Chapter 20
- Function of hCG and pregnancy
- References
- Chapter 21
- Pituitary sulfated hCG
- References
- Chapter 22
- Hyperglycosylated hCG and extravillous cytotrophoblast hCG
- References
- Chapter 23
- hCG and pregnancy tests
- References
- Chapter 24
- False-positive hCG pregnancy tests
- Chapter 25
- Implantation and pregnancy failure
- References
- Chapter 26
- Deep implantation, hCG, gestational hypertension, and preeclampsia
- References
- Chapter 27
- hCG, gestational trophoblastic diseases, and choriocarcinoma
- Hydatidiform mole
- Choriocarcinoma
- References
- Chapter 28
- Ovarian cystic disorders
- Follicular cyst
- Corpus luteum cyst
- Polycystic ovary syndrome (PCOS)
- Further reading
- Chapter 29
- Illicit use of hCG in dietary programs and to promote anabolism
- Dietary programs
- hCG and anabolism promotion
- hCG variants as dangerous substances
- References
- Chapter 30
- Cancer hCG, hyperglycosylated hCG, extravillous cytotrophoblastic hCG and TGFb receptor 2
- References
- Chapter 31
- hCG molecules produced in cancer inhibit apoptosis and cell death, a process which can be overturned by specific antibodies: paving a way towards targeted adjuvant cancer immunotherapy.
- Introduction
- Methods
- Materials
- Sheep Antisera Studies
- CDX1307 Study
- Results
- In-House Sheep Antisera
- Early Apoptosis with AnnexinV and P.I. Staining and Cell Cycle FACS Histogram
- CDX1307 Murine Antisera
- Cell Number Assay and Cell Viability Comparison
- CDX1307 Human Antisera
- Cell Number Assay and Cell Viability Comparison
- Cell Cycle and Apoptosis Assay
- Discussion
- Acknowledgments
- References
- Abbreviations
- Index
- Back cover.