One, no one, one hundred thousand : the multifaceted role of macrophages in health and disease. Part A /

Detalles Bibliográficos
Clasificación:Libro Electrónico
Otros Autores: Mariani, Samanta A., Cassetta, Luca, Galluzzi, Lorenzo
Formato: eBook
Idioma:Inglés
Publicado: Cambridge, UK : Academic Press is an imprint of Elsevier, 2022.
Colección:International review of cell and molecular biology ; v. 367
Temas:
Macrophages.
Macrophages
Acceso en línea:Texto completo
Tabla de Contenidos:
  • Intro
  • One, No one, One Hundred Thousand
  • The Multifaceted Role of Macrophages in Health and Disease
  • Part A
  • Copyright
  • Contents
  • Contributors
  • Chapter One: Pulmonary macrophages and SARS-Cov2 infection
  • 1. Introduction
  • 2. Macrophages in the healthy lung
  • 2.1. Alveolar macrophages
  • 2.2. Interstitial macrophages
  • 3. Inflammation as a driver of COVID-19 severity
  • 4. Macrophage as mediators of organ damage in COVID-19?
  • 4.1. Defining the macrophage compartment in COVID-19
  • 4.2. The role of macrophage subsets in SARS-CoV-2 infection
  • 5. Targeting the macrophage in severe COVID-19: Current and future therapeutics?
  • Acknowledgments
  • References
  • Chapter Two: Macrophage control of Crohn�s disease
  • 1. Introduction
  • 2. Development of intestinal macrophages
  • 3. Localization and heterogeneity of intestinal macrophages
  • 4. Functional properties of intestinal macrophages
  • 5. Maintenance of homeostatic macrophage function
  • 6. Macrophages in Crohn�s disease
  • 7. Macrophages contribute to in intestinal inflammation in CD
  • 8. Macrophage functions and dysfunctions in Crohn�s disease
  • 9. Targeting macrophages to improve Crohn�s disease
  • Acknowledgments
  • References
  • Chapter Three: Metabolism in tumor-associated macrophages
  • 1. Introduction
  • 2. Glucose metabolism
  • 2.1. Regulation of glucose metabolism in TAMs
  • 2.2. Glucose metabolism in TAM function
  • 3. Amino acid metabolism
  • 3.1. Regulation of amino acid metabolism
  • 3.2. Amino acid metabolism in TAM function
  • 4. Lipid metabolism in TAM
  • 4.1. Fatty acid metabolism
  • 4.2. Arachidonic acid metabolism
  • 4.3. Cholesterol metabolism
  • 5. Targeting TAM metabolism for therapy
  • 6. Conclusion
  • References
  • Chapter Four: Macrophages in the kidney in health, injury and repair
  • 1. Introduction
  • 2. Identification of renal macrophages.
  • 3. Ontology of renal macrophage and their role in the developing kidney
  • 3.1. Developmental origin of kidney macrophages
  • 3.2. Roles of macrophages in kidney development
  • 4. Macrophage phenotypic heterogeneity
  • 4.1. Macrophage activation states
  • 4.2. Mononuclear phagocyte phenotyping in the era of single cell RNA sequencing
  • 4.3. Single cell RNA sequencing in the healthy kidney
  • 4.4. Single cell RNA sequencing studies in kidney disease
  • 5. Role of macrophages in renal immunosurveillance
  • 6. Macrophages in renal injury
  • 6.1. Pro-inflammatory macrophages predominate during acute kidney injury
  • 6.2. Macrophage activation in chronic kidney disease
  • 6.3. Macrophage to myofibroblast transition
  • 7. Macrophages in renal repair
  • 8. Therapeutic prospects
  • 9. Conclusions
  • References
  • Chapter Five: Heterogeneity and function of macrophages in the breast during homeostasis and cancer
  • 1. Introduction
  • 2. Mammary gland macrophages
  • 2.1. Development and structure of the mammary gland
  • 2.2. Macrophage heterogeneity in the mammary gland
  • 2.3. Localization and role of macrophages in the mammary gland
  • 3. Breast cancer
  • 4. Macrophages in breast cancer
  • 4.1. Macrophage heterogeneity in breast cancer
  • 4.2. Impact of hypoxia on the heterogeneity and functions of TAMs in breast cancer
  • 5. Concluding remarks and future perspectives
  • Competing interests
  • Funding
  • References
  • Chapter Six: Endometrial macrophages in health and disease
  • 1. Introduction
  • 2. Endometrial physiology
  • 3. Endometrial macrophages-Origin, location and abundance
  • 4. Identification and characterization of endometrial macrophages
  • 5. Regulation of macrophage function during the menstrual cycle
  • 5.1. Decidualization
  • 5.2. Menstruation
  • 6. Endometrial macrophages in women�s reproductive health disorders.
  • 6.1. Macrophages in endometriosis
  • 6.2. Macrophages in abnormal uterine bleeding
  • 7. Future directions
  • 8. Conclusions
  • Acknowledgments
  • Conflict of interest
  • References.

Ejemplares similares